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Fusion gene ID: 16108 |
FusionGeneSummary for HERC3_PSPH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HERC3_PSPH | Fusion gene ID: 16108 | Hgene | Tgene | Gene symbol | HERC3 | PSPH | Gene ID | 8916 | 5723 |
| Gene name | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | phosphoserine phosphatase | |
| Synonyms | - | PSP|PSPHD | |
| Cytomap | 4q22.1 | 7p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable E3 ubiquitin-protein ligase HERC3HECT domain and RCC1-like domain-containing protein 3HECT-type E3 ubiquitin transferase HERC3hect domain and RLD 3 | phosphoserine phosphataseL-3-phosphoserine phosphataseO-phosphoserine phosphohydrolasePSPase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q15034 | P78330 | |
| Ensembl transtripts involved in fusion gene | ENST00000402738, ENST00000407637, ENST00000601319, ENST00000264345, ENST00000543130, | ENST00000275605, ENST00000395471, ENST00000459834, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 12 X 13 X 4=624 |
| # samples | 4 | 14 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/624*10)=-2.15611920191728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HERC3 [Title/Abstract] AND PSPH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PSPH | GO:0006563 | L-serine metabolic process | 15291819 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DC340871 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000402738 | ENST00000275605 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000402738 | ENST00000395471 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000402738 | ENST00000459834 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000407637 | ENST00000275605 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000407637 | ENST00000395471 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000407637 | ENST00000459834 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000601319 | ENST00000275605 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000601319 | ENST00000395471 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000601319 | ENST00000459834 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000264345 | ENST00000275605 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000264345 | ENST00000395471 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000264345 | ENST00000459834 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000543130 | ENST00000275605 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000543130 | ENST00000395471 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
| intron-intron | ENST00000543130 | ENST00000459834 | HERC3 | chr4 | 89606033 | - | PSPH | chr7 | 56131998 | + |
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FusionProtFeatures for HERC3_PSPH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HERC3 | PSPH |