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Fusion gene ID: 16090 |
FusionGeneSummary for HEPH_ZC3H12B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HEPH_ZC3H12B | Fusion gene ID: 16090 | Hgene | Tgene | Gene symbol | HEPH | ZC3H12B | Gene ID | 9843 | 340554 |
| Gene name | hephaestin | zinc finger CCCH-type containing 12B | |
| Synonyms | CPL | CXorf32|MCPIP2 | |
| Cytomap | Xq12 | Xq11.2-q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hephaestin | probable ribonuclease ZC3H12BMCP-induced protein 2zinc finger CCCH domain-containing protein 12B | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q9BQS7 | Q5HYM0 | |
| Ensembl transtripts involved in fusion gene | ENST00000519389, ENST00000374727, ENST00000336279, ENST00000441993, ENST00000419594, ENST00000343002, | ENST00000423889, ENST00000338957, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: HEPH [Title/Abstract] AND ZC3H12B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-AD-6899-01A | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000519389 | ENST00000423889 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000519389 | ENST00000338957 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000374727 | ENST00000423889 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000374727 | ENST00000338957 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000336279 | ENST00000423889 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000336279 | ENST00000338957 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000441993 | ENST00000423889 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000441993 | ENST00000338957 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000419594 | ENST00000423889 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000419594 | ENST00000338957 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000343002 | ENST00000423889 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
| 5CDS-intron | ENST00000343002 | ENST00000338957 | HEPH | chrX | 65428088 | + | ZC3H12B | chrX | 64708526 | + |
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FusionProtFeatures for HEPH_ZC3H12B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HEPH | ZC3H12B |