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Fusion gene ID: 16081 |
FusionGeneSummary for HELZ_PTPRN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HELZ_PTPRN | Fusion gene ID: 16081 | Hgene | Tgene | Gene symbol | HELZ | PTPRN | Gene ID | 9931 | 5798 |
| Gene name | helicase with zinc finger | protein tyrosine phosphatase, receptor type N | |
| Synonyms | DHRC|DRHC|HUMORF5 | IA-2|IA-2/PTP|IA2|ICA512|R-PTP-N | |
| Cytomap | 17q24.2 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable helicase with zinc finger domaindown-regulated in human cancers proteinhelicase with zinc finger domain | receptor-type tyrosine-protein phosphatase-like NICA 512PTP IA-2insulinoma-associated tyrosine-phosphatase-like proteinislet cell antigen 2islet cell antigen 512islet cell autoantigen 3protein tyrosine phosphatase-like N | |
| Modification date | 20180526 | 20180522 | |
| UniProtAcc | P42694 | Q16849 | |
| Ensembl transtripts involved in fusion gene | ENST00000358691, ENST00000580168, ENST00000580662, | ENST00000409251, ENST00000295718, ENST00000423636, ENST00000497977, | |
| Fusion gene scores | * DoF score | 17 X 16 X 7=1904 | 2 X 2 X 1=4 |
| # samples | 17 | 2 | |
| ** MAII score | log2(17/1904*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: HELZ [Title/Abstract] AND PTPRN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPRN | GO:0000302 | response to reactive oxygen species | 18048354 |
| Tgene | PTPRN | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15596545 |
| Tgene | PTPRN | GO:1904692 | positive regulation of type B pancreatic cell proliferation | 18178618 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP389573 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000358691 | ENST00000409251 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-3UTR | ENST00000358691 | ENST00000295718 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-intron | ENST00000358691 | ENST00000423636 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-intron | ENST00000358691 | ENST00000497977 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-3UTR | ENST00000580168 | ENST00000409251 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-3UTR | ENST00000580168 | ENST00000295718 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-intron | ENST00000580168 | ENST00000423636 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-intron | ENST00000580168 | ENST00000497977 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-3UTR | ENST00000580662 | ENST00000409251 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-3UTR | ENST00000580662 | ENST00000295718 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-intron | ENST00000580662 | ENST00000423636 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
| intron-intron | ENST00000580662 | ENST00000497977 | HELZ | chr17 | 65149848 | + | PTPRN | chr2 | 220154559 | - |
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FusionProtFeatures for HELZ_PTPRN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HELZ | PTPRN |