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Fusion gene ID: 16037 |
FusionGeneSummary for HECTD1_SCFD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HECTD1_SCFD1 | Fusion gene ID: 16037 | Hgene | Tgene | Gene symbol | HECTD1 | SCFD1 | Gene ID | 25831 | 23256 |
| Gene name | HECT domain E3 ubiquitin protein ligase 1 | sec1 family domain containing 1 | |
| Synonyms | EULIR | C14orf163|RA410|SLY1|SLY1P|STXBP1L2 | |
| Cytomap | 14q12 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase HECTD1E3 ligase for inhibin receptorHECT domain containing E3 ubiquitin protein ligase 1HECT domain-containing protein 1HECT-type E3 ubiquitin transferase HECTD1 | sec1 family domain-containing protein 1syntaxin-binding protein 1-like 2vesicle transport-related protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9ULT8 | Q8WVM8 | |
| Ensembl transtripts involved in fusion gene | ENST00000399332, ENST00000553700, ENST00000556474, | ENST00000458591, ENST00000421551, ENST00000544052, ENST00000541123, ENST00000396629, ENST00000554486, | |
| Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 7 X 6 X 5=210 |
| # samples | 12 | 7 | |
| ** MAII score | log2(12/320*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HECTD1 [Title/Abstract] AND SCFD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A2FR-01A | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000399332 | ENST00000458591 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000399332 | ENST00000421551 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000399332 | ENST00000544052 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000399332 | ENST00000541123 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000399332 | ENST00000396629 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| 5CDS-intron | ENST00000399332 | ENST00000554486 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000553700 | ENST00000458591 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000553700 | ENST00000421551 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000553700 | ENST00000544052 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000553700 | ENST00000541123 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| Frame-shift | ENST00000553700 | ENST00000396629 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| 5CDS-intron | ENST00000553700 | ENST00000554486 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| intron-3CDS | ENST00000556474 | ENST00000458591 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| intron-3CDS | ENST00000556474 | ENST00000421551 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| intron-3CDS | ENST00000556474 | ENST00000544052 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| intron-3CDS | ENST00000556474 | ENST00000541123 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| intron-3CDS | ENST00000556474 | ENST00000396629 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
| intron-intron | ENST00000556474 | ENST00000554486 | HECTD1 | chr14 | 31626046 | - | SCFD1 | chr14 | 31177196 | + |
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FusionProtFeatures for HECTD1_SCFD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HECTD1 | SCFD1 |