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Fusion gene ID: 15954 |
FusionGeneSummary for HDAC7_CHUK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HDAC7_CHUK | Fusion gene ID: 15954 | Hgene | Tgene | Gene symbol | HDAC7 | CHUK | Gene ID | 51564 | 1147 |
| Gene name | histone deacetylase 7 | conserved helix-loop-helix ubiquitous kinase | |
| Synonyms | HD7|HD7A|HDAC7A | IKBKA|IKK-alpha|IKK1|IKKA|NFKBIKA|TCF16 | |
| Cytomap | 12q13.11 | 10q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone deacetylase 7histone deacetylase 7A | inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase 1I-kappa-B kinase-alphaIKK-a kinaseIkB kinase alpha subunitNuclear factor NFkappaB inhibitor kinase alphaTCF-16transcription factor 16 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8WUI4 | O15111 | |
| Ensembl transtripts involved in fusion gene | ENST00000080059, ENST00000354334, ENST00000552960, ENST00000380610, ENST00000427332, ENST00000488927, | ENST00000370397, ENST00000590930, | |
| Fusion gene scores | * DoF score | 9 X 6 X 6=324 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: HDAC7 [Title/Abstract] AND CHUK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HDAC7 | GO:0032703 | negative regulation of interleukin-2 production | 17360565 |
| Tgene | CHUK | GO:0006468 | protein phosphorylation | 20434986 |
| Tgene | CHUK | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055 |
| Tgene | CHUK | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA482203 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000080059 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| 5CDS-intron | ENST00000080059 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| In-frame | ENST00000354334 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| 5CDS-intron | ENST00000354334 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| In-frame | ENST00000552960 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| 5CDS-intron | ENST00000552960 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-3CDS | ENST00000380610 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-intron | ENST00000380610 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-3CDS | ENST00000427332 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-intron | ENST00000427332 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-3CDS | ENST00000488927 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-intron | ENST00000488927 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
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FusionProtFeatures for HDAC7_CHUK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HDAC7 | CHUK |