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Fusion gene ID: 15914 |
FusionGeneSummary for HCP5_TMEM232 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HCP5_TMEM232 | Fusion gene ID: 15914 | Hgene | Tgene | Gene symbol | HCP5 | TMEM232 | Gene ID | 10866 | 642987 |
| Gene name | HLA complex P5 | transmembrane protein 232 | |
| Synonyms | 6S2650E|D6S2650E|P5-1 | - | |
| Cytomap | 6p21.33 | 5q22.1 | |
| Type of gene | ncRNA | protein-coding | |
| Description | HLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORF | transmembrane protein 232 | |
| Modification date | 20180519 | 20180403 | |
| UniProtAcc | C9JQI7 | ||
| Ensembl transtripts involved in fusion gene | ENST00000414046, ENST00000419355, ENST00000457127, ENST00000423496, | ENST00000515518, ENST00000429839, ENST00000455884, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 11 X 7 X 4=308 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/308*10)=-1.77493344436523 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HCP5 [Title/Abstract] AND TMEM232 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-LL-A7SZ-01A | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000414046 | ENST00000515518 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| 3UTR-intron | ENST00000414046 | ENST00000429839 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| 3UTR-intron | ENST00000414046 | ENST00000455884 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000419355 | ENST00000515518 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000419355 | ENST00000429839 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000419355 | ENST00000455884 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000457127 | ENST00000515518 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000457127 | ENST00000429839 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000457127 | ENST00000455884 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000423496 | ENST00000515518 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000423496 | ENST00000429839 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
| intron-intron | ENST00000423496 | ENST00000455884 | HCP5 | chr6 | 31368540 | + | TMEM232 | chr5 | 109625141 | - |
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FusionProtFeatures for HCP5_TMEM232 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HCP5 | TMEM232 |