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Fusion gene ID: 15904 |
FusionGeneSummary for HCK_ENG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HCK_ENG | Fusion gene ID: 15904 | Hgene | Tgene | Gene symbol | HCK | ENG | Gene ID | 3055 | 2022 |
| Gene name | HCK proto-oncogene, Src family tyrosine kinase | endoglin | |
| Synonyms | JTK9|p59Hck|p61Hck | END|HHT1|ORW1 | |
| Cytomap | 20q11.21 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase HCKhematopoietic cell kinasehemopoietic cell kinasep59-HCK/p60-HCK | endoglinCD105 antigen | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P08631 | P17813 | |
| Ensembl transtripts involved in fusion gene | ENST00000534862, ENST00000538448, ENST00000375862, ENST00000520553, ENST00000518730, ENST00000375852, | ENST00000373203, ENST00000344849, ENST00000480266, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 3=108 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HCK [Title/Abstract] AND ENG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HCK | GO:0071801 | regulation of podosome assembly | 15998323 |
| Hgene | HCK | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 15998323 |
| Tgene | ENG | GO:0001934 | positive regulation of protein phosphorylation | 12015308 |
| Tgene | ENG | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 12015308 |
| Tgene | ENG | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 15702480 |
| Tgene | ENG | GO:0030336 | negative regulation of cell migration | 19736306 |
| Tgene | ENG | GO:0030513 | positive regulation of BMP signaling pathway | 17068149 |
| Tgene | ENG | GO:0031953 | negative regulation of protein autophosphorylation | 12015308 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI026800 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + | ||
| ChiTaRS3.1 | BI026773 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000534862 | ENST00000373203 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000534862 | ENST00000344849 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000534862 | ENST00000480266 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000538448 | ENST00000373203 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000538448 | ENST00000344849 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000538448 | ENST00000480266 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000375862 | ENST00000373203 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000375862 | ENST00000344849 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000375862 | ENST00000480266 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000520553 | ENST00000373203 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000520553 | ENST00000344849 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000520553 | ENST00000480266 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000518730 | ENST00000373203 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000518730 | ENST00000344849 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000518730 | ENST00000480266 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000375852 | ENST00000373203 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000375852 | ENST00000344849 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
| intron-intron | ENST00000375852 | ENST00000480266 | HCK | chr20 | 30669564 | - | ENG | chr9 | 130588650 | + |
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FusionProtFeatures for HCK_ENG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HCK | ENG |