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Fusion gene ID: 15862 |
FusionGeneSummary for HBA2_CSH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HBA2_CSH2 | Fusion gene ID: 15862 | Hgene | Tgene | Gene symbol | HBA2 | CSH2 | Gene ID | 3040 | 1443 |
| Gene name | hemoglobin subunit alpha 2 | chorionic somatomammotropin hormone 2 | |
| Synonyms | HBA-T2|HBH | CS-2|CSB|GHB1|PL|hCS-B | |
| Cytomap | 16p13.3 | 17q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hemoglobin subunit alphaalpha globinalpha-2 globinhemoglobin alpha chainhemoglobin, alpha 2mutant hemoglobin alpha 2 globin chain | chorionic somatomammotropin hormone 2choriomammotropinchorionic somatomammotropin Bgrowth hormone B1lactogenplacental lactogen | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P69905 | ||
| Ensembl transtripts involved in fusion gene | ENST00000251595, ENST00000397806, | ENST00000345366, ENST00000336844, ENST00000392886, ENST00000560142, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 5 X 5 X 2=50 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: HBA2 [Title/Abstract] AND CSH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HBA2 | GO:0010942 | positive regulation of cell death | 19740759 |
| Hgene | HBA2 | GO:0042542 | response to hydrogen peroxide | 19740759 |
| Hgene | HBA2 | GO:0042744 | hydrogen peroxide catabolic process | 19740759 |
| Hgene | HBA2 | GO:0051291 | protein heterooligomerization | 19740759 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DR979761 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000251595 | ENST00000345366 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| 5CDS-3UTR | ENST00000251595 | ENST00000336844 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| 5CDS-3UTR | ENST00000251595 | ENST00000392886 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| 5CDS-3UTR | ENST00000251595 | ENST00000560142 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| In-frame | ENST00000397806 | ENST00000345366 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| 5CDS-3UTR | ENST00000397806 | ENST00000336844 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| 5CDS-3UTR | ENST00000397806 | ENST00000392886 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
| 5CDS-3UTR | ENST00000397806 | ENST00000560142 | HBA2 | chr16 | 223310 | + | CSH2 | chr17 | 61949525 | - |
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FusionProtFeatures for HBA2_CSH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HBA2 | CSH2 |