|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 15839 |
FusionGeneSummary for HAT1_EXOC6B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HAT1_EXOC6B | Fusion gene ID: 15839 | Hgene | Tgene | Gene symbol | HAT1 | EXOC6B | Gene ID | 8520 | 23233 |
| Gene name | histone acetyltransferase 1 | exocyst complex component 6B | |
| Synonyms | KAT1 | SEC15B|SEC15L2 | |
| Cytomap | 2q31.1 | 2p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone acetyltransferase type B catalytic subunit | exocyst complex component 6BSEC15 homolog BSEC15-like protein 2exocyst complex component Sec15B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O14929 | Q9Y2D4 | |
| Ensembl transtripts involved in fusion gene | ENST00000392584, ENST00000460481, ENST00000264108, | ENST00000272427, ENST00000490919, ENST00000410104, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 7 X 4=224 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HAT1 [Title/Abstract] AND EXOC6B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HAT1 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Hgene | HAT1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Hgene | HAT1 | GO:0043967 | histone H4 acetylation | 22615379 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-05-4420-01A | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000392584 | ENST00000272427 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| 5CDS-5UTR | ENST00000392584 | ENST00000490919 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| 5CDS-intron | ENST00000392584 | ENST00000410104 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| intron-3CDS | ENST00000460481 | ENST00000272427 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| intron-5UTR | ENST00000460481 | ENST00000490919 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| intron-intron | ENST00000460481 | ENST00000410104 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| In-frame | ENST00000264108 | ENST00000272427 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| 5CDS-5UTR | ENST00000264108 | ENST00000490919 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
| 5CDS-intron | ENST00000264108 | ENST00000410104 | HAT1 | chr2 | 172844276 | + | EXOC6B | chr2 | 72411316 | - |
Top |
FusionProtFeatures for HAT1_EXOC6B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HAT1 | EXOC6B |
| Acetylates soluble but not nucleosomal histone H4 at'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent,acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsicsubstrate specificity that modifies lysine in recognition sequenceGXGKXG. May be involved in nucleosome assembly during DNAreplication and repair as part of the histone H3.1 and H3.3complexes. May play a role in DNA repair in response to freeradical damage. {ECO:0000269|PubMed:11585814,ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379,ECO:0000269|PubMed:9427644}. | Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000264108 | + | 10 | 11 | 241_243 | 364 | 420 | Region | Acetyl-CoA binding |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000264108 | + | 10 | 11 | 248_254 | 364 | 420 | Region | Acetyl-CoA binding |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000392584 | + | 9 | 10 | 241_243 | 279 | 335 | Region | Acetyl-CoA binding |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000392584 | + | 9 | 10 | 248_254 | 279 | 335 | Region | Acetyl-CoA binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | EXOC6B | chr2:172844276 | chr2:72411316 | ENST00000272427 | - | 19 | 22 | 50_119 | 732 | 812 | Coiled coil | Ontology_term=ECO:0000255 |
Top |
FusionGeneSequence for HAT1_EXOC6B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HAT1_ENST00000392584_chr2_172844276_+_EXOC6B_ENST00000272427_chr2_72411316_-_359aa MFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYH ERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYT EFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDI >In-frame_HAT1_ENST00000264108_chr2_172844276_+_EXOC6B_ENST00000272427_chr2_72411316_-_444aa MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVE YASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQT FLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTV LDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HAT1_ENST00000392584_chr2_172844276_+_EXOC6B_ENST00000272427_chr2_72411316_-_1077nt ATGTTCCGTGTTGAATATGCATCTAAAGTTGATGAGAACTTTGACTGTGTAGAGGCAGATGATGTTGAGGGCAAAATTAGACAAATCATT CCACCTGGATTTTGCACAAACACGAATGATTTCCTTTCTTTACTGGAAAAGGAAGTTGATTTCAAGCCATTCGGAACCTTACTTCATACC TACTCAGTTCTCAGTCCAACAGGAGGAGAAAACTTTACCTTTCAGATATATAAGGCTGACATGACATGTAGAGGCTTTCGAGAATATCAT GAAAGGCTTCAGACCTTTTTGATGTGGTTTATTGAAACTGCTAGCTTTATTGACGTGGATGATGAAAGATGGCACTACTTTCTAGTATTT GAGAAGTATAATAAGGATGGAGCTACGCTCTTTGCGACCGTAGGCTACATGACAGTCTATAATTACTATGTGTACCCAGACAAAACCCGG CCACGTGTAAGTCAGATGCTGATTTTGACTCCATTTCAAGGTCAAGGCCATGGTGCTCAACTTCTTGAAACAGTTCATAGATACTACACT GAATTTCCTACAGTTCTTGATATTACAGCGGAAGATCCATCCAAAAGCTATGTGAAATTACGAGACTTTGTGCTTGTGAAGCTTTGTCAA GATTTGCCCTGTTTTTCCCGGGAAAAATTAATGCAAGGATTCAATGAAGATATGGCGATAGAGGCACAACAGAAGTTCAAAATAAATAAG CAACACGCTAGAAGGGTTTATGAAATTCTTCGACTACTGGTAACTGACATGAGTGATGCCGAACAATACAGAAGCTACAGACTGGATATT AAAAGAAGACTAATTAGCCCATATAAGCTTTTGGATCTTTTCATCCAGTGGGATTGGTCAACCTACCTTGCTGACTATGGTCAGCCCAAC TGCAAGTACCTCCGGGTAAACCCAGTGACTGCTCTGACCCTGCTTGAGAAGATGAAGGATACTAGCCGCAAGAACAACATGTTTGCACAG >In-frame_HAT1_ENST00000264108_chr2_172844276_+_EXOC6B_ENST00000272427_chr2_72411316_-_1332nt ATGGCGGGATTTGGTGCTATGGAGAAATTTTTGGTAGAATATAAGAGTGCAGTGGAGAAGAAACTGGCAGAGTACAAATGTAACACCAAC ACAGCAATTGAACTAAAATTAGTTCGTTTTCCTGAAGATCTTGAAAATGACATTAGAACTTTCTTTCCTGAGTATACCCATCAACTCTTT GGGGATGATGAAACTGCTTTTGGTTACAAGGGTCTAAAGATCCTGTTATACTATATTGCTGGTAGCCTGTCAACAATGTTCCGTGTTGAA TATGCATCTAAAGTTGATGAGAACTTTGACTGTGTAGAGGCAGATGATGTTGAGGGCAAAATTAGACAAATCATTCCACCTGGATTTTGC ACAAACACGAATGATTTCCTTTCTTTACTGGAAAAGGAAGTTGATTTCAAGCCATTCGGAACCTTACTTCATACCTACTCAGTTCTCAGT CCAACAGGAGGAGAAAACTTTACCTTTCAGATATATAAGGCTGACATGACATGTAGAGGCTTTCGAGAATATCATGAAAGGCTTCAGACC TTTTTGATGTGGTTTATTGAAACTGCTAGCTTTATTGACGTGGATGATGAAAGATGGCACTACTTTCTAGTATTTGAGAAGTATAATAAG GATGGAGCTACGCTCTTTGCGACCGTAGGCTACATGACAGTCTATAATTACTATGTGTACCCAGACAAAACCCGGCCACGTGTAAGTCAG ATGCTGATTTTGACTCCATTTCAAGGTCAAGGCCATGGTGCTCAACTTCTTGAAACAGTTCATAGATACTACACTGAATTTCCTACAGTT CTTGATATTACAGCGGAAGATCCATCCAAAAGCTATGTGAAATTACGAGACTTTGTGCTTGTGAAGCTTTGTCAAGATTTGCCCTGTTTT TCCCGGGAAAAATTAATGCAAGGATTCAATGAAGATATGGCGATAGAGGCACAACAGAAGTTCAAAATAAATAAGCAACACGCTAGAAGG GTTTATGAAATTCTTCGACTACTGGTAACTGACATGAGTGATGCCGAACAATACAGAAGCTACAGACTGGATATTAAAAGAAGACTAATT AGCCCATATAAGCTTTTGGATCTTTTCATCCAGTGGGATTGGTCAACCTACCTTGCTGACTATGGTCAGCCCAACTGCAAGTACCTCCGG GTAAACCCAGTGACTGCTCTGACCCTGCTTGAGAAGATGAAGGATACTAGCCGCAAGAACAACATGTTTGCACAGTTTCGGAAAAATGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HAT1_ENST00000392584_chr2_172844276_+_EXOC6B_ENST00000272427_chr2_72411316_-_4660nt GAGCGCGCGGGTTGATTCGTCCTTCCTCAGCCGCGGGTGATCGTAGCTCGGAAATGGCGGGATTTGGTGCTATGGAGAAATTTTTGGTAG AATATAAGAGTGCAGTGGAGAAGAAACTGGCAGAGTACAAATGTAACACCAACACAGCAATTGAACTAAAATTAGTGAAACTGCTTTTGG TTACAAGGGTCTAAAGATCCTGTTATACTATATTGCTGGTAGCCTGTCAACAATGTTCCGTGTTGAATATGCATCTAAAGTTGATGAGAA CTTTGACTGTGTAGAGGCAGATGATGTTGAGGGCAAAATTAGACAAATCATTCCACCTGGATTTTGCACAAACACGAATGATTTCCTTTC TTTACTGGAAAAGGAAGTTGATTTCAAGCCATTCGGAACCTTACTTCATACCTACTCAGTTCTCAGTCCAACAGGAGGAGAAAACTTTAC CTTTCAGATATATAAGGCTGACATGACATGTAGAGGCTTTCGAGAATATCATGAAAGGCTTCAGACCTTTTTGATGTGGTTTATTGAAAC TGCTAGCTTTATTGACGTGGATGATGAAAGATGGCACTACTTTCTAGTATTTGAGAAGTATAATAAGGATGGAGCTACGCTCTTTGCGAC CGTAGGCTACATGACAGTCTATAATTACTATGTGTACCCAGACAAAACCCGGCCACGTGTAAGTCAGATGCTGATTTTGACTCCATTTCA AGGTCAAGGCCATGGTGCTCAACTTCTTGAAACAGTTCATAGATACTACACTGAATTTCCTACAGTTCTTGATATTACAGCGGAAGATCC ATCCAAAAGCTATGTGAAATTACGAGACTTTGTGCTTGTGAAGCTTTGTCAAGATTTGCCCTGTTTTTCCCGGGAAAAATTAATGCAAGG ATTCAATGAAGATATGGCGATAGAGGCACAACAGAAGTTCAAAATAAATAAGCAACACGCTAGAAGGGTTTATGAAATTCTTCGACTACT GGTAACTGACATGAGTGATGCCGAACAATACAGAAGCTACAGACTGGATATTAAAAGAAGACTAATTAGCCCATATAAGCTTTTGGATCT TTTCATCCAGTGGGATTGGTCAACCTACCTTGCTGACTATGGTCAGCCCAACTGCAAGTACCTCCGGGTAAACCCAGTGACTGCTCTGAC CCTGCTTGAGAAGATGAAGGATACTAGCCGCAAGAACAACATGTTTGCACAGTTTCGGAAAAATGAGCGAGACAAGCAGAAACTCATTGA CACCGTGGCCAAGCAGCTCCGAGGACTCATCAGCAGCCACCACTCATGAAGGGTGACCCCGGACCCACAGAGGCGACCTGCTGCAGCCTC TGTGTCAGTCTGGGGTCCAGCCCCAGCTGACCCTGCATTTGTGCATTCTTCTTCAAAGAGAGCATATGTATTTTTTTATTAACCCCTGTG CAGTATTCACATAACATTTCCCTATAGTAAAAGAGGCACAAGAATAAGCAAGTACATGAGATGTTGCTAGGCTGGGACTCAGGGGAAGTT ATTACTACACTATCTGTGTTATCTTAGAGATGGTGGTATCATCAATTCCACAGTGATGAACCACCTTTCATCCATGGCTCTAAAGCTTAG GTCTGGGGCTTAGGAACCATAAAAAGTGGGTATCTGGCGCTGGGAGGTAGAGTGAGTAAGCAAAAGGATACTAAAATATGTCCTGTTCAC TCTTGGATGCCCATTCACCACATAGATGAGGCTGATTCTTCTCAATACAAGGAAAGGGCATGGCAAACATTACTATTTAGTACACTAAGG GCAGCTCTGGAGGGTCATCTCCTCAGTCTGCTGACTTTCACTGGCTTGTGAACAAGCATGGCATATGGCAAGATGACAGCTTCATTCCAA TCCCCCAAGAATGGCGGTTTCTTTAGCCTGATCTAACCCCAGGCTTTTATTGCAATTTTTTCTAGGGCAGGATACAGCTAAGTAGACAGC AGTAATAATTGGATCCCATGTTTAACTGCATATTGCCCCAGCTCTAGGAGTGTTGAGTCTCAACTCGAAGAGTTTTTCTGGATCTTGAAA GCCAGTTTTCATGGAATCAGAGACCCAATCCCTTCCCTGTTCATCTCATTTCCTTCACTTACAGTCAGAGCACTTGGTTCAGGACATAAA TCAACAGTTACTTCCATAGGCCTTCACAGGGCGTTTCAGACTTAGCCTCCTCCAGTAATGCCATTGAAATAGTTCAGATTTCGGAAGCCT AAAAATGGCCTTTACCTTACCCTTAGGTGTAACCTGAGGATTAGTTGGGATTGTTCCTTTATGTTTTAAAACCAGCTTTTTGGTTATCAT CTTTAAGGAAATGTCACCAGCTCTGCACTGTGGGGGCAGCCATGCCTGGACTGGATGCCTCTAGGGATGGAGACATTGTTACCATAAAGT CGACAGAGCCAACCATGGCTTGTGGCTTGTTGCCTCTGGCCCAACTGTCCTTCACTAAATAATATCCTAGATATTATTTTGTTGCTCAAG CCCAAGGTTCCCACCCTCTTTTGAGATCCCCAAAGCCATCTTTGGCCTTGTCTAAGAAAGATTGCCTATAATCCTGTCCTCCAAACTCTA AAGCCTGGAGCAGCTTAGCGTGGAGGCTGCACTCATTGACCCAGATGGACTCCTGAGACTTAACGCAAGGGCTTTGCTATGAGGTCAGTC GGGGGAAACTGTACTTTAAGACACTTCAGAAAGATGCTACTGGCTAGTAGCAGAAAGATGGCTAGTGGCAAGAGTATAATTGTGCATCAC CAAACAATGACAAATAAGCCACACAGGCATTTCCAGCTTGGATTGATGGGAGGAGAGACTCATCAAACAGAATTCTTCACTACCTTTGTC AGCTACTGAGTTGCTTCTGGGGAGGGAAGTACTTCCTTGCCCCTCCCCAACCCCCCTACCTCACCATATCCTATCATATCTTGATAGTCA TGGGGAAGAGGATGTGCACACAGACATACAAATTTCCTCAAAGCTGGAGAGACCAGGCTACATGTGAGCTCATAGATGCTGCTGAGGCTC ATCCTGAGGGCTGGATGGTTGGCCAGGGTTTCAGAATGAGGGTAAGGGATGAGCACTGCCACCCAGAACTTGATAAGCCAAGAGAAGGCA GGAGCCAAAATGGCATCGCCAAGCTCTCATCTTTGTTGAAACAAGTGAGAAACGATTATATTAATCTGAAGTTCTATTGCTTGAGAAGAG TTCAAAACACTTCTCTTTGCTAGTACCCAGTTTGCAGCAAGATCTCTTCAGCTTTAAGTGCTGAGAGACTTTGAAGTGGAAATGGAGAGA TGTGTAAGCATGGCACAGTGTTTGTCTTTTTAGAGGATCATCATTGCTGGTCTGGTCTCAAACCTCTGCCTTGGAAGAACTGTGCTATAC AGGAAAAAGTGAACAAGGTGGAGGAATAGGGGTTATTCTGCACAGAAGTCCCATGAAAGGAAAAGCTTATTCAAGCTCAAGACATAAAGA TGGACCCTTTGATATATCTTCTCTCCATTCTTAGTCTGCCTTCACCTTATCTAACAAAAAACAACATGCAGCTACTGAGTTGTATGTAGA GACATACTCTTGGTGGGCCAGGGAAGGTAAAAACAGGGACCAGCAATGTCAAGTTTTTGAACTAGAAAAGTGGGATGTTTTTAGTTTTGT CTATAACCTGTAGCTGGGCCAACCCTTGAGAGGACTTGTGCAAAGCATGTGTGCCCAGACCCATCAGACTCCTCAGATATGGCCTCAAAT ACCTAGAGATGTAGAAGTACCGTGGAGGGCCTCAATAAGAGGGCAAGCACACAGATGGCTAGAAGCCTGTATGGCTTCTGGTCAGGATGA ACCCTTGGCCAAGTTCTTGAGGAAACCAGGTCTATATTCCTGAAGGGACAGTTCAGTTTGGGACTCTATTAGGTTTCAGTAGTAATATAG GCTGCTTGCATCATTTTAACATTCATAGGGAAAATCTCTTTGAGCAGGCTATAAATGAAGCTGTTGCAGGTAGGGAAGAACAGGACCTGA AAATGGGAACCAGGAAGTGAGATCCTGTTGGCAAAGGGAATGTAGAGCTTCCAGGGTGCATTGCCCACTGTTCTCATTGCATACCAGTCC TCCAAGTCAGTCTAGCCTTACTGTACACTTGACAAGTGCTTACTCAGCAAGTCCCAGACCCACGGCCTTTTATCTCCCAAGACTGGCTTT GGCCATGACCTTCCTCATCAGGCCTCTGAGCACACTCTCTAGGAACTGCTGCAGAAATTCCCCTACCTTAGCCTCCCTTCTCCCAGGACT CCTCTCTTGACTGCAATTGCCTCTTCTTCTTCTTCTTCTTCTTCCTTTTTGTTTTTTTTTTTTTTGCCTGCATTCACAATTACTTTTCAC AAAGGTGTTGGAAATGGCATTTTTATTTTACACAGATAGTTGCACATATATAGAGAAAATTAGGAAAGTCCATTTTTAACTCTAAAGGGA ACTTTTTTCTCTAAAACTTACTTGTAAAGCTACTGATACAGATGGGCCGCATGGTTAGGGGAAAGCTCCTCTGTGAAAAGAGCATGTTTA >In-frame_HAT1_ENST00000264108_chr2_172844276_+_EXOC6B_ENST00000272427_chr2_72411316_-_4719nt CGTCCTTCCTCAGCCGCGGGTGATCGTAGCTCGGAAATGGCGGGATTTGGTGCTATGGAGAAATTTTTGGTAGAATATAAGAGTGCAGTG GAGAAGAAACTGGCAGAGTACAAATGTAACACCAACACAGCAATTGAACTAAAATTAGTTCGTTTTCCTGAAGATCTTGAAAATGACATT AGAACTTTCTTTCCTGAGTATACCCATCAACTCTTTGGGGATGATGAAACTGCTTTTGGTTACAAGGGTCTAAAGATCCTGTTATACTAT ATTGCTGGTAGCCTGTCAACAATGTTCCGTGTTGAATATGCATCTAAAGTTGATGAGAACTTTGACTGTGTAGAGGCAGATGATGTTGAG GGCAAAATTAGACAAATCATTCCACCTGGATTTTGCACAAACACGAATGATTTCCTTTCTTTACTGGAAAAGGAAGTTGATTTCAAGCCA TTCGGAACCTTACTTCATACCTACTCAGTTCTCAGTCCAACAGGAGGAGAAAACTTTACCTTTCAGATATATAAGGCTGACATGACATGT AGAGGCTTTCGAGAATATCATGAAAGGCTTCAGACCTTTTTGATGTGGTTTATTGAAACTGCTAGCTTTATTGACGTGGATGATGAAAGA TGGCACTACTTTCTAGTATTTGAGAAGTATAATAAGGATGGAGCTACGCTCTTTGCGACCGTAGGCTACATGACAGTCTATAATTACTAT GTGTACCCAGACAAAACCCGGCCACGTGTAAGTCAGATGCTGATTTTGACTCCATTTCAAGGTCAAGGCCATGGTGCTCAACTTCTTGAA ACAGTTCATAGATACTACACTGAATTTCCTACAGTTCTTGATATTACAGCGGAAGATCCATCCAAAAGCTATGTGAAATTACGAGACTTT GTGCTTGTGAAGCTTTGTCAAGATTTGCCCTGTTTTTCCCGGGAAAAATTAATGCAAGGATTCAATGAAGATATGGCGATAGAGGCACAA CAGAAGTTCAAAATAAATAAGCAACACGCTAGAAGGGTTTATGAAATTCTTCGACTACTGGTAACTGACATGAGTGATGCCGAACAATAC AGAAGCTACAGACTGGATATTAAAAGAAGACTAATTAGCCCATATAAGCTTTTGGATCTTTTCATCCAGTGGGATTGGTCAACCTACCTT GCTGACTATGGTCAGCCCAACTGCAAGTACCTCCGGGTAAACCCAGTGACTGCTCTGACCCTGCTTGAGAAGATGAAGGATACTAGCCGC AAGAACAACATGTTTGCACAGTTTCGGAAAAATGAGCGAGACAAGCAGAAACTCATTGACACCGTGGCCAAGCAGCTCCGAGGACTCATC AGCAGCCACCACTCATGAAGGGTGACCCCGGACCCACAGAGGCGACCTGCTGCAGCCTCTGTGTCAGTCTGGGGTCCAGCCCCAGCTGAC CCTGCATTTGTGCATTCTTCTTCAAAGAGAGCATATGTATTTTTTTATTAACCCCTGTGCAGTATTCACATAACATTTCCCTATAGTAAA AGAGGCACAAGAATAAGCAAGTACATGAGATGTTGCTAGGCTGGGACTCAGGGGAAGTTATTACTACACTATCTGTGTTATCTTAGAGAT GGTGGTATCATCAATTCCACAGTGATGAACCACCTTTCATCCATGGCTCTAAAGCTTAGGTCTGGGGCTTAGGAACCATAAAAAGTGGGT ATCTGGCGCTGGGAGGTAGAGTGAGTAAGCAAAAGGATACTAAAATATGTCCTGTTCACTCTTGGATGCCCATTCACCACATAGATGAGG CTGATTCTTCTCAATACAAGGAAAGGGCATGGCAAACATTACTATTTAGTACACTAAGGGCAGCTCTGGAGGGTCATCTCCTCAGTCTGC TGACTTTCACTGGCTTGTGAACAAGCATGGCATATGGCAAGATGACAGCTTCATTCCAATCCCCCAAGAATGGCGGTTTCTTTAGCCTGA TCTAACCCCAGGCTTTTATTGCAATTTTTTCTAGGGCAGGATACAGCTAAGTAGACAGCAGTAATAATTGGATCCCATGTTTAACTGCAT ATTGCCCCAGCTCTAGGAGTGTTGAGTCTCAACTCGAAGAGTTTTTCTGGATCTTGAAAGCCAGTTTTCATGGAATCAGAGACCCAATCC CTTCCCTGTTCATCTCATTTCCTTCACTTACAGTCAGAGCACTTGGTTCAGGACATAAATCAACAGTTACTTCCATAGGCCTTCACAGGG CGTTTCAGACTTAGCCTCCTCCAGTAATGCCATTGAAATAGTTCAGATTTCGGAAGCCTAAAAATGGCCTTTACCTTACCCTTAGGTGTA ACCTGAGGATTAGTTGGGATTGTTCCTTTATGTTTTAAAACCAGCTTTTTGGTTATCATCTTTAAGGAAATGTCACCAGCTCTGCACTGT GGGGGCAGCCATGCCTGGACTGGATGCCTCTAGGGATGGAGACATTGTTACCATAAAGTCGACAGAGCCAACCATGGCTTGTGGCTTGTT GCCTCTGGCCCAACTGTCCTTCACTAAATAATATCCTAGATATTATTTTGTTGCTCAAGCCCAAGGTTCCCACCCTCTTTTGAGATCCCC AAAGCCATCTTTGGCCTTGTCTAAGAAAGATTGCCTATAATCCTGTCCTCCAAACTCTAAAGCCTGGAGCAGCTTAGCGTGGAGGCTGCA CTCATTGACCCAGATGGACTCCTGAGACTTAACGCAAGGGCTTTGCTATGAGGTCAGTCGGGGGAAACTGTACTTTAAGACACTTCAGAA AGATGCTACTGGCTAGTAGCAGAAAGATGGCTAGTGGCAAGAGTATAATTGTGCATCACCAAACAATGACAAATAAGCCACACAGGCATT TCCAGCTTGGATTGATGGGAGGAGAGACTCATCAAACAGAATTCTTCACTACCTTTGTCAGCTACTGAGTTGCTTCTGGGGAGGGAAGTA CTTCCTTGCCCCTCCCCAACCCCCCTACCTCACCATATCCTATCATATCTTGATAGTCATGGGGAAGAGGATGTGCACACAGACATACAA ATTTCCTCAAAGCTGGAGAGACCAGGCTACATGTGAGCTCATAGATGCTGCTGAGGCTCATCCTGAGGGCTGGATGGTTGGCCAGGGTTT CAGAATGAGGGTAAGGGATGAGCACTGCCACCCAGAACTTGATAAGCCAAGAGAAGGCAGGAGCCAAAATGGCATCGCCAAGCTCTCATC TTTGTTGAAACAAGTGAGAAACGATTATATTAATCTGAAGTTCTATTGCTTGAGAAGAGTTCAAAACACTTCTCTTTGCTAGTACCCAGT TTGCAGCAAGATCTCTTCAGCTTTAAGTGCTGAGAGACTTTGAAGTGGAAATGGAGAGATGTGTAAGCATGGCACAGTGTTTGTCTTTTT AGAGGATCATCATTGCTGGTCTGGTCTCAAACCTCTGCCTTGGAAGAACTGTGCTATACAGGAAAAAGTGAACAAGGTGGAGGAATAGGG GTTATTCTGCACAGAAGTCCCATGAAAGGAAAAGCTTATTCAAGCTCAAGACATAAAGATGGACCCTTTGATATATCTTCTCTCCATTCT TAGTCTGCCTTCACCTTATCTAACAAAAAACAACATGCAGCTACTGAGTTGTATGTAGAGACATACTCTTGGTGGGCCAGGGAAGGTAAA AACAGGGACCAGCAATGTCAAGTTTTTGAACTAGAAAAGTGGGATGTTTTTAGTTTTGTCTATAACCTGTAGCTGGGCCAACCCTTGAGA GGACTTGTGCAAAGCATGTGTGCCCAGACCCATCAGACTCCTCAGATATGGCCTCAAATACCTAGAGATGTAGAAGTACCGTGGAGGGCC TCAATAAGAGGGCAAGCACACAGATGGCTAGAAGCCTGTATGGCTTCTGGTCAGGATGAACCCTTGGCCAAGTTCTTGAGGAAACCAGGT CTATATTCCTGAAGGGACAGTTCAGTTTGGGACTCTATTAGGTTTCAGTAGTAATATAGGCTGCTTGCATCATTTTAACATTCATAGGGA AAATCTCTTTGAGCAGGCTATAAATGAAGCTGTTGCAGGTAGGGAAGAACAGGACCTGAAAATGGGAACCAGGAAGTGAGATCCTGTTGG CAAAGGGAATGTAGAGCTTCCAGGGTGCATTGCCCACTGTTCTCATTGCATACCAGTCCTCCAAGTCAGTCTAGCCTTACTGTACACTTG ACAAGTGCTTACTCAGCAAGTCCCAGACCCACGGCCTTTTATCTCCCAAGACTGGCTTTGGCCATGACCTTCCTCATCAGGCCTCTGAGC ACACTCTCTAGGAACTGCTGCAGAAATTCCCCTACCTTAGCCTCCCTTCTCCCAGGACTCCTCTCTTGACTGCAATTGCCTCTTCTTCTT CTTCTTCTTCTTCCTTTTTGTTTTTTTTTTTTTTGCCTGCATTCACAATTACTTTTCACAAAGGTGTTGGAAATGGCATTTTTATTTTAC ACAGATAGTTGCACATATATAGAGAAAATTAGGAAAGTCCATTTTTAACTCTAAAGGGAACTTTTTTCTCTAAAACTTACTTGTAAAGCT ACTGATACAGATGGGCCGCATGGTTAGGGGAAAGCTCCTCTGTGAAAAGAGCATGTTTATTCCTCTTGTACATTTTCCTCTTTTAACTGC |
Top |
FusionGenePPI for HAT1_EXOC6B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HAT1 | BAP1, G3BP1, ATG10, HIST1H4A, HIST3H3, RBBP7, ASF1B, IPO4, HIST1H3A, H3F3A, H2AFX, HIST1H3E, HIST4H4, BCL2A1, CUL3, COPS5, ACAA1, HIST2H4A, HIST2H2AC, TP53BP1, YWHAQ, ZGPAT, HSPA1A, MEOX2, RBBP4, REL, TCF4, TNFAIP1, RPS6KB2, UNK, C5orf51, AP2M1, DDI2, TTC4, VPS29, SNF8, TLN2, NTRK1, NASP, ASF1A, CRY2, FAM204A, VTN, PRKAA2 | EXOC6B | EGFR, MTERF1, CA14, DTNBP1, SCN2B, EXOC5, EXOC7, EXOC8, NTRK1, IL1R2, EXOC3, EXOC1, EPHA1, EXOC4, EXOC2, EXOC6, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000264108 | + | 10 | 11 | 62_64 | 364 | 420 | histone H4 N-terminus |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000392584 | + | 9 | 10 | 62_64 | 279 | 335 | histone H4 N-terminus |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000264108 | + | 10 | 11 | 225_227 | 364 | 420 | histone H4 N-terminus |
| Hgene | HAT1 | chr2:172844276 | chr2:72411316 | ENST00000392584 | + | 9 | 10 | 225_227 | 279 | 335 | histone H4 N-terminus |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HAT1_EXOC6B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HAT1_EXOC6B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|