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Fusion gene ID: 15830 |
FusionGeneSummary for HARBI1_PTPRS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HARBI1_PTPRS | Fusion gene ID: 15830 | Hgene | Tgene | Gene symbol | HARBI1 | PTPRS | Gene ID | 283254 | 5802 |
| Gene name | harbinger transposase derived 1 | protein tyrosine phosphatase, receptor type S | |
| Synonyms | C11orf77 | PTPSIGMA|R-PTP-S|R-PTP-sigma | |
| Cytomap | 11p11.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | putative nuclease HARBI1harbinger transposase-derived nuclease | receptor-type tyrosine-protein phosphatase Sprotein tyrosine phosphatase PTPsigmareceptor-type tyrosine-protein phosphatase sigma | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q96MB7 | Q13332 | |
| Ensembl transtripts involved in fusion gene | ENST00000326737, | ENST00000588552, ENST00000262963, ENST00000372412, ENST00000348075, ENST00000357368, ENST00000353284, ENST00000587303, ENST00000588012, ENST00000592099, ENST00000590509, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 5 X 5=125 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/4*10)=2.90689059560852 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HARBI1 [Title/Abstract] AND PTPRS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPRS | GO:0006470 | protein dephosphorylation | 8524829 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-14-0789-01A | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000326737 | ENST00000588552 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000262963 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000372412 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000348075 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000357368 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000353284 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000587303 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000588012 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-5UTR | ENST00000326737 | ENST00000592099 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
| 5CDS-intron | ENST00000326737 | ENST00000590509 | HARBI1 | chr11 | 46637118 | - | PTPRS | chr19 | 5246056 | - |
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FusionProtFeatures for HARBI1_PTPRS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HARBI1 | PTPRS |