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Fusion gene ID: 1583 |
FusionGeneSummary for AMBP_ORM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AMBP_ORM1 | Fusion gene ID: 1583 | Hgene | Tgene | Gene symbol | AMBP | ORM1 | Gene ID | 259 | 5004 |
| Gene name | alpha-1-microglobulin/bikunin precursor | orosomucoid 1 | |
| Synonyms | A1M|EDC1|HCP|HI30|IATIL|ITI|ITIL|ITILC|UTI | AGP-A|AGP1|HEL-S-153w|ORM | |
| Cytomap | 9q32 | 9q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein AMBPbikunincomplex-forming glycoprotein heterogeneous in chargegrowth-inhibiting protein 19inter-alpha-trypsin inhibitor light chainprotein HCtrypstatinuristatinuronic-acid-rich protein | alpha-1-acid glycoprotein 1AGP 1OMD 1epididymis secretory sperm binding protein Li 153w | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P02760 | P02763 | |
| Ensembl transtripts involved in fusion gene | ENST00000265132, | ENST00000259396, ENST00000538816, ENST00000477456, | |
| Fusion gene scores | * DoF score | 5 X 3 X 1=15 | 5 X 5 X 3=75 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AMBP [Title/Abstract] AND ORM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ORM1 | GO:0032715 | negative regulation of interleukin-6 production | 23973664 |
| Tgene | ORM1 | GO:0032720 | negative regulation of tumor necrosis factor production | 23973664 |
| Tgene | ORM1 | GO:0050716 | positive regulation of interleukin-1 secretion | 8774350 |
| Tgene | ORM1 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 8774350 |
| Tgene | ORM1 | GO:1904469 | positive regulation of tumor necrosis factor secretion | 8774350 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-DD-A4NH-01A | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000265132 | ENST00000259396 | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
| 5CDS-intron | ENST00000265132 | ENST00000538816 | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
| 5CDS-intron | ENST00000265132 | ENST00000477456 | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
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FusionProtFeatures for AMBP_ORM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AMBP | ORM1 |