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Fusion gene ID: 15819 |
FusionGeneSummary for HAND2_SLC30A9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HAND2_SLC30A9 | Fusion gene ID: 15819 | Hgene | Tgene | Gene symbol | HAND2 | SLC30A9 | Gene ID | 9464 | 10463 |
| Gene name | heart and neural crest derivatives expressed 2 | solute carrier family 30 member 9 | |
| Synonyms | DHAND2|Hed|Thing2|bHLHa26|dHand | BILAPES|C4orf1|GAC63|HUEL|ZNT9 | |
| Cytomap | 4q34.1 | 4p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heart- and neural crest derivatives-expressed protein 2basic helix-loop-helix transcription factor HAND2class A basic helix-loop-helix protein 26deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 | zinc transporter 9GRIP1-dependent nuclear receptor coactivatorexpressed in human embryonic lunghuman embryonic lung proteinsolute carrier family 30 (zinc transporter), member 9znT-9 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P61296 | Q6PML9 | |
| Ensembl transtripts involved in fusion gene | ENST00000359562, ENST00000505300, | ENST00000264451, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 5 X 3=45 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HAND2 [Title/Abstract] AND SLC30A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HAND2 | GO:0010613 | positive regulation of cardiac muscle hypertrophy | 24161931 |
| Hgene | HAND2 | GO:0034103 | regulation of tissue remodeling | 24161931 |
| Hgene | HAND2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15486975|16280598|24161931 |
| Hgene | HAND2 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 16280598 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PCPG | TCGA-SP-A6QI-01A | HAND2 | chr4 | 174449886 | - | SLC30A9 | chr4 | 42041003 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000359562 | ENST00000264451 | HAND2 | chr4 | 174449886 | - | SLC30A9 | chr4 | 42041003 | + |
| intron-3CDS | ENST00000505300 | ENST00000264451 | HAND2 | chr4 | 174449886 | - | SLC30A9 | chr4 | 42041003 | + |
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FusionProtFeatures for HAND2_SLC30A9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HAND2 | SLC30A9 |