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Fusion gene ID: 15806 |
FusionGeneSummary for HADHA_PRKAR1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HADHA_PRKAR1B | Fusion gene ID: 15806 | Hgene | Tgene | Gene symbol | HADHA | PRKAR1B | Gene ID | 3030 | 5575 |
| Gene name | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | protein kinase cAMP-dependent type I regulatory subunit beta | |
| Synonyms | ECHA|GBP|HADH|LCEH|LCHAD|MTPA|TP-ALPHA | PRKAR1 | |
| Cytomap | 2p23.3 | 7p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trifunctional enzyme subunit alpha, mitochondrial3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit3-oxoacyl-CoA thiolase78 kDa gastrin-binding proteingastrin-binding proteinhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase ( | cAMP-dependent protein kinase type I-beta regulatory subunitprotein kinase, cAMP-dependent, regulatory subunit type I betaprotein kinase, cAMP-dependent, regulatory, type I, beta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P40939 | P31321 | |
| Ensembl transtripts involved in fusion gene | ENST00000380649, ENST00000457468, ENST00000461025, | ENST00000544935, ENST00000537384, ENST00000406797, ENST00000403562, ENST00000360274, ENST00000488474, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 7 X 7 X 4=196 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HADHA [Title/Abstract] AND PRKAR1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKAR1B | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 21812984 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-QK-A8Z9-01B | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000380649 | ENST00000544935 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000380649 | ENST00000537384 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000380649 | ENST00000406797 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000380649 | ENST00000403562 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000380649 | ENST00000360274 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| 5CDS-intron | ENST00000380649 | ENST00000488474 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000457468 | ENST00000544935 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000457468 | ENST00000537384 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000457468 | ENST00000406797 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000457468 | ENST00000403562 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| Frame-shift | ENST00000457468 | ENST00000360274 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| 5CDS-intron | ENST00000457468 | ENST00000488474 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| intron-3CDS | ENST00000461025 | ENST00000544935 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| intron-3CDS | ENST00000461025 | ENST00000537384 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| intron-3CDS | ENST00000461025 | ENST00000406797 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| intron-3CDS | ENST00000461025 | ENST00000403562 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| intron-3CDS | ENST00000461025 | ENST00000360274 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
| intron-intron | ENST00000461025 | ENST00000488474 | HADHA | chr2 | 26453060 | - | PRKAR1B | chr7 | 635941 | - |
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FusionProtFeatures for HADHA_PRKAR1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HADHA | PRKAR1B |