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Fusion gene ID: 158 |
FusionGeneSummary for ABCC4_CCDC169 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABCC4_CCDC169 | Fusion gene ID: 158 | Hgene | Tgene | Gene symbol | ABCC4 | CCDC169 | Gene ID | 10257 | 728591 |
| Gene name | ATP binding cassette subfamily C member 4 | coiled-coil domain containing 169 | |
| Synonyms | MOAT-B|MOATB|MRP4 | C13orf38 | |
| Cytomap | 13q32.1 | 13q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | multidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter | coiled-coil domain-containing protein 169RP11-251J8.1 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | O15439 | A6NNP5 | |
| Ensembl transtripts involved in fusion gene | ENST00000412704, ENST00000376887, ENST00000536256, ENST00000431522, ENST00000538287, ENST00000474158, | ENST00000503173, ENST00000239860, ENST00000491049, ENST00000379864, ENST00000510088, ENST00000379862, ENST00000239859, ENST00000477250, | |
| Fusion gene scores | * DoF score | 6 X 6 X 7=252 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ABCC4 [Title/Abstract] AND CCDC169 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABCC4 | GO:0032310 | prostaglandin secretion | 25173977 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-VP-A876-01A | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000412704 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000412704 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000412704 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000412704 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000412704 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000412704 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000412704 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000412704 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000376887 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000376887 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000376887 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000376887 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000376887 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000376887 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000376887 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000376887 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000536256 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000536256 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000536256 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000536256 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000536256 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000536256 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000536256 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000536256 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000431522 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000431522 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000431522 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| Frame-shift | ENST00000431522 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000431522 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000431522 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000431522 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 5CDS-intron | ENST00000431522 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-3CDS | ENST00000538287 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-3CDS | ENST00000538287 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-3CDS | ENST00000538287 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-3CDS | ENST00000538287 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-intron | ENST00000538287 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-intron | ENST00000538287 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-intron | ENST00000538287 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| 3UTR-intron | ENST00000538287 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-3CDS | ENST00000474158 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-3CDS | ENST00000474158 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-3CDS | ENST00000474158 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-3CDS | ENST00000474158 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-intron | ENST00000474158 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-intron | ENST00000474158 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-intron | ENST00000474158 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
| intron-intron | ENST00000474158 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
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FusionProtFeatures for ABCC4_CCDC169 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABCC4 | CCDC169 |