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Fusion gene ID: 15755 |
FusionGeneSummary for H19_WDR62 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: H19_WDR62 | Fusion gene ID: 15755 | Hgene | Tgene | Gene symbol | H19 | WDR62 | Gene ID | 283120 | 284403 |
| Gene name | H19, imprinted maternally expressed transcript | WD repeat domain 62 | |
| Synonyms | ASM|ASM1|BWS|D11S813E|LINC00008|NCRNA00008|WT2 | C19orf14|MCPH2 | |
| Cytomap | 11p15.5 | 19q13.12 | |
| Type of gene | ncRNA | protein-coding | |
| Description | H19, imprinted maternally expressed transcript (non-protein coding)H19, imprinted maternally expressed untranslated mRNAlong intergenic non-protein coding RNA 8 | WD repeat-containing protein 62microcephaly, primary autosomal recessive 2truncated WDR62 | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | O43379 | ||
| Ensembl transtripts involved in fusion gene | ENST00000390168, | ENST00000388999, ENST00000401500, ENST00000270301, ENST00000378860, | |
| Fusion gene scores | * DoF score | 19 X 23 X 1=437 | 4 X 3 X 4=48 |
| # samples | 30 | 4 | |
| ** MAII score | log2(30/437*10)=-0.542670779004717 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: H19 [Title/Abstract] AND WDR62 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF118081 | H19 | chr11 | 2019035 | + | WDR62 | chr19 | 36561143 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000390168 | ENST00000388999 | H19 | chr11 | 2019035 | + | WDR62 | chr19 | 36561143 | + |
| intron-intron | ENST00000390168 | ENST00000401500 | H19 | chr11 | 2019035 | + | WDR62 | chr19 | 36561143 | + |
| intron-intron | ENST00000390168 | ENST00000270301 | H19 | chr11 | 2019035 | + | WDR62 | chr19 | 36561143 | + |
| intron-intron | ENST00000390168 | ENST00000378860 | H19 | chr11 | 2019035 | + | WDR62 | chr19 | 36561143 | + |
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FusionProtFeatures for H19_WDR62 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| H19 | WDR62 |