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Fusion gene ID: 1570 |
FusionGeneSummary for ALPK1_GALNTL6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALPK1_GALNTL6 | Fusion gene ID: 1570 | Hgene | Tgene | Gene symbol | ALPK1 | GALNTL6 | Gene ID | 80216 | 442117 |
| Gene name | alpha kinase 1 | polypeptide N-acetylgalactosaminyltransferase like 6 | |
| Synonyms | 8430410J10Rik|LAK | GALNACT20|GALNT17|GalNAc-T6L | |
| Cytomap | 4q25 | 4q34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-protein kinase 1chromosome 4 kinaselymphocyte alpha-kinaselymphocyte alpha-protein kinase | polypeptide N-acetylgalactosaminyltransferase-like 6GaNTase 17GalNAc transferase 17UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20UDP-N-acetyl-alpha-D-gala | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96QP1 | Q49A17 | |
| Ensembl transtripts involved in fusion gene | ENST00000458497, ENST00000177648, ENST00000504176, ENST00000505912, | ENST00000506823, ENST00000508122, ENST00000457021, ENST00000511251, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 7 X 5 X 7=245 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALPK1 [Title/Abstract] AND GALNTL6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GALNTL6 | GO:0018243 | protein O-linked glycosylation via threonine | 22186971 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-LK-A4NY-01A | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000458497 | ENST00000506823 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-3CDS | ENST00000458497 | ENST00000508122 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-intron | ENST00000458497 | ENST00000457021 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-intron | ENST00000458497 | ENST00000511251 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-3CDS | ENST00000177648 | ENST00000506823 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-3CDS | ENST00000177648 | ENST00000508122 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-intron | ENST00000177648 | ENST00000457021 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-intron | ENST00000177648 | ENST00000511251 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-3CDS | ENST00000504176 | ENST00000506823 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-3CDS | ENST00000504176 | ENST00000508122 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-intron | ENST00000504176 | ENST00000457021 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| 5UTR-intron | ENST00000504176 | ENST00000511251 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| intron-3CDS | ENST00000505912 | ENST00000506823 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| intron-3CDS | ENST00000505912 | ENST00000508122 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| intron-intron | ENST00000505912 | ENST00000457021 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
| intron-intron | ENST00000505912 | ENST00000511251 | ALPK1 | chr4 | 113218625 | + | GALNTL6 | chr4 | 173803941 | + |
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FusionProtFeatures for ALPK1_GALNTL6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALPK1 | GALNTL6 |