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Fusion gene ID: 15688 |
FusionGeneSummary for GUCY1A2_NLK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GUCY1A2_NLK | Fusion gene ID: 15688 | Hgene | Tgene | Gene symbol | GUCY1A2 | NLK | Gene ID | 2977 | 51701 |
| Gene name | guanylate cyclase 1 soluble subunit alpha 2 | nemo like kinase | |
| Synonyms | GC-SA2|GUC1A2 | - | |
| Cytomap | 11q22.3 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanylate cyclase soluble subunit alpha-2GCS-alpha-2guanylate cyclase 1, soluble, alpha 2 | serine/threonine-protein kinase NLK | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P33402 | Q9UBE8 | |
| Ensembl transtripts involved in fusion gene | ENST00000526355, ENST00000282249, ENST00000347596, | ENST00000407008, ENST00000583517, ENST00000582037, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 7 X 4=224 |
| # samples | 2 | 11 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(11/224*10)=-1.02599520853294 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GUCY1A2 [Title/Abstract] AND NLK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NLK | GO:0050821 | protein stabilization | 25512613 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-2F-A9KO-01A | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000526355 | ENST00000407008 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000526355 | ENST00000583517 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000526355 | ENST00000582037 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| In-frame | ENST00000282249 | ENST00000407008 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000282249 | ENST00000583517 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000282249 | ENST00000582037 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| In-frame | ENST00000347596 | ENST00000407008 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000347596 | ENST00000583517 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000347596 | ENST00000582037 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
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FusionProtFeatures for GUCY1A2_NLK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GUCY1A2 | NLK |