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Fusion gene ID: 15635 |
FusionGeneSummary for GTF2H3_NCOR2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GTF2H3_NCOR2 | Fusion gene ID: 15635 | Hgene | Tgene | Gene symbol | GTF2H3 | NCOR2 | Gene ID | 2967 | 9612 |
| Gene name | general transcription factor IIH subunit 3 | nuclear receptor corepressor 2 | |
| Synonyms | BTF2|P34|TFB4|TFIIH | CTG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1 | |
| Cytomap | 12q24.31 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | general transcription factor IIH subunit 3TFIIH basal transcription factor complex p34 subunitbasic transcription factor 2 34 kDa subunitgeneral transcription factor IIH, polypeptide 3, 34kDa | nuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressor | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q13889 | Q9Y618 | |
| Ensembl transtripts involved in fusion gene | ENST00000228955, ENST00000543341, | ENST00000405201, ENST00000404621, ENST00000404121, ENST00000356219, ENST00000397355, ENST00000429285, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 10 X 10 X 6=600 |
| # samples | 5 | 11 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/600*10)=-2.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GTF2H3 [Title/Abstract] AND NCOR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GTF2H3 | GO:0006366 | transcription by RNA polymerase II | 9852112|27193682 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A3C1-06A | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000228955 | ENST00000405201 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000228955 | ENST00000404621 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000228955 | ENST00000404121 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000228955 | ENST00000356219 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000228955 | ENST00000397355 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000228955 | ENST00000429285 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000543341 | ENST00000405201 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000543341 | ENST00000404621 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000543341 | ENST00000404121 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000543341 | ENST00000356219 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000543341 | ENST00000397355 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
| Frame-shift | ENST00000543341 | ENST00000429285 | GTF2H3 | chr12 | 124130108 | + | NCOR2 | chr12 | 124862930 | - |
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FusionProtFeatures for GTF2H3_NCOR2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GTF2H3 | NCOR2 |