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Fusion gene ID: 1559 |
FusionGeneSummary for ALK_MSN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALK_MSN | Fusion gene ID: 1559 | Hgene | Tgene | Gene symbol | ALK | MSN | Gene ID | 238 | 4478 |
| Gene name | ALK receptor tyrosine kinase | moesin | |
| Synonyms | CD246|NBLST3 | HEL70|IMD50 | |
| Cytomap | 2p23.2-p23.1 | Xq12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase | moesinepididymis luminal protein 70membrane-organizing extension spike protein | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | Q9UM73 | P26038 | |
| Ensembl transtripts involved in fusion gene | ENST00000389048, ENST00000431873, ENST00000498037, | ENST00000609205, ENST00000360270, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 6 X 6 X 2=72 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALK [Title/Abstract] AND MSN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALK | GO:0016310 | phosphorylation | 9174053 |
| Hgene | ALK | GO:0046777 | protein autophosphorylation | 9174053 |
| Tgene | MSN | GO:0001771 | immunological synapse formation | 27405666 |
| Tgene | MSN | GO:0042098 | T cell proliferation | 27405666 |
| Tgene | MSN | GO:0070489 | T cell aggregation | 27405666 |
| Tgene | MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
| Tgene | MSN | GO:0072678 | T cell migration | 27405666 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF295079 | ALK | chr2 | 29446408 | - | MSN | chrX | 64958868 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000389048 | ENST00000609205 | ALK | chr2 | 29446408 | - | MSN | chrX | 64958868 | + |
| intron-intron | ENST00000389048 | ENST00000360270 | ALK | chr2 | 29446408 | - | MSN | chrX | 64958868 | + |
| intron-intron | ENST00000431873 | ENST00000609205 | ALK | chr2 | 29446408 | - | MSN | chrX | 64958868 | + |
| intron-intron | ENST00000431873 | ENST00000360270 | ALK | chr2 | 29446408 | - | MSN | chrX | 64958868 | + |
| intron-intron | ENST00000498037 | ENST00000609205 | ALK | chr2 | 29446408 | - | MSN | chrX | 64958868 | + |
| intron-intron | ENST00000498037 | ENST00000360270 | ALK | chr2 | 29446408 | - | MSN | chrX | 64958868 | + |
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FusionProtFeatures for ALK_MSN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALK | MSN |