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Fusion gene ID: 15547 |
FusionGeneSummary for GSK3B_SEMA5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GSK3B_SEMA5B | Fusion gene ID: 15547 | Hgene | Tgene | Gene symbol | GSK3B | SEMA5B | Gene ID | 2932 | 54437 |
| Gene name | glycogen synthase kinase 3 beta | semaphorin 5B | |
| Synonyms | - | SEMAG|SemG | |
| Cytomap | 3q13.33 | 3q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycogen synthase kinase-3 betaGSK-3 betaGSK3beta isoformserine/threonine-protein kinase GSK3B | semaphorin-5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P49841 | Q9P283 | |
| Ensembl transtripts involved in fusion gene | ENST00000264235, ENST00000316626, ENST00000473886, | ENST00000357599, ENST00000195173, ENST00000451055, ENST00000465147, | |
| Fusion gene scores | * DoF score | 24 X 16 X 8=3072 | 4 X 4 X 3=48 |
| # samples | 26 | 4 | |
| ** MAII score | log2(26/3072*10)=-3.5625946876927 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GSK3B [Title/Abstract] AND SEMA5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GSK3B | GO:0005977 | glycogen metabolic process | 8638126 |
| Hgene | GSK3B | GO:0006468 | protein phosphorylation | 11035810|16315267|20937854 |
| Hgene | GSK3B | GO:0006983 | ER overload response | 14744935 |
| Hgene | GSK3B | GO:0018105 | peptidyl-serine phosphorylation | 8638126|11104755|11955436|14744935|17139249 |
| Hgene | GSK3B | GO:0018107 | peptidyl-threonine phosphorylation | 11955436|17139249|25897075 |
| Hgene | GSK3B | GO:0031175 | neuron projection development | 19830702 |
| Hgene | GSK3B | GO:0031334 | positive regulation of protein complex assembly | 8638126 |
| Hgene | GSK3B | GO:0032091 | negative regulation of protein binding | 16890161 |
| Hgene | GSK3B | GO:0035556 | intracellular signal transduction | 14749367 |
| Hgene | GSK3B | GO:0043066 | negative regulation of apoptotic process | 14744935 |
| Hgene | GSK3B | GO:0046777 | protein autophosphorylation | 23184662 |
| Hgene | GSK3B | GO:0046827 | positive regulation of protein export from nucleus | 14744935 |
| Hgene | GSK3B | GO:0060070 | canonical Wnt signaling pathway | 18787224 |
| Hgene | GSK3B | GO:1901215 | negative regulation of neuron death | 19830702 |
| Hgene | GSK3B | GO:1901216 | positive regulation of neuron death | 18508033 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-ZG-A9KY-01A | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| TCGA | LD | PRAD | TCGA-ZG-A9KY-01A | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000264235 | ENST00000357599 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5CDS-5UTR | ENST00000264235 | ENST00000195173 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5CDS-5UTR | ENST00000264235 | ENST00000451055 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5CDS-intron | ENST00000264235 | ENST00000465147 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5CDS-5UTR | ENST00000316626 | ENST00000357599 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5CDS-5UTR | ENST00000316626 | ENST00000195173 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5CDS-5UTR | ENST00000316626 | ENST00000451055 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5CDS-intron | ENST00000316626 | ENST00000465147 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5UTR-5UTR | ENST00000473886 | ENST00000357599 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5UTR-5UTR | ENST00000473886 | ENST00000195173 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5UTR-5UTR | ENST00000473886 | ENST00000451055 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| 5UTR-intron | ENST00000473886 | ENST00000465147 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122680148 | - |
| In-frame | ENST00000264235 | ENST00000357599 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| In-frame | ENST00000264235 | ENST00000195173 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| In-frame | ENST00000264235 | ENST00000451055 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| 5CDS-5UTR | ENST00000264235 | ENST00000465147 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| In-frame | ENST00000316626 | ENST00000357599 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| In-frame | ENST00000316626 | ENST00000195173 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| In-frame | ENST00000316626 | ENST00000451055 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| 5CDS-5UTR | ENST00000316626 | ENST00000465147 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| 5UTR-3CDS | ENST00000473886 | ENST00000357599 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| 5UTR-3CDS | ENST00000473886 | ENST00000195173 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| 5UTR-3CDS | ENST00000473886 | ENST00000451055 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
| 5UTR-5UTR | ENST00000473886 | ENST00000465147 | GSK3B | chr3 | 119582266 | - | SEMA5B | chr3 | 122667556 | - |
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FusionProtFeatures for GSK3B_SEMA5B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GSK3B | SEMA5B |