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Fusion gene ID: 15524 |
FusionGeneSummary for GSK3A_CNFN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GSK3A_CNFN | Fusion gene ID: 15524 | Hgene | Tgene | Gene symbol | GSK3A | CNFN | Gene ID | 2931 | 84518 |
| Gene name | glycogen synthase kinase 3 alpha | cornifelin | |
| Synonyms | - | PLAC8L2 | |
| Cytomap | 19q13.2 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycogen synthase kinase-3 alphaGSK-3 alphaserine/threonine-protein kinase GSK3A | cornifelincornefied envelope protein cornefilin | |
| Modification date | 20180522 | 20180403 | |
| UniProtAcc | P49840 | Q9BYD5 | |
| Ensembl transtripts involved in fusion gene | ENST00000222330, ENST00000398249, | ENST00000222032, ENST00000597255, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 2 X 1 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: GSK3A [Title/Abstract] AND CNFN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GSK3A | GO:0006468 | protein phosphorylation | 11035810 |
| Hgene | GSK3A | GO:0018107 | peptidyl-threonine phosphorylation | 25897075 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-2V-A95S-01A | GSK3A | chr19 | 42736209 | - | CNFN | chr19 | 42893191 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000222330 | ENST00000222032 | GSK3A | chr19 | 42736209 | - | CNFN | chr19 | 42893191 | - |
| 5CDS-5UTR | ENST00000222330 | ENST00000597255 | GSK3A | chr19 | 42736209 | - | CNFN | chr19 | 42893191 | - |
| 5CDS-5UTR | ENST00000398249 | ENST00000222032 | GSK3A | chr19 | 42736209 | - | CNFN | chr19 | 42893191 | - |
| 5CDS-5UTR | ENST00000398249 | ENST00000597255 | GSK3A | chr19 | 42736209 | - | CNFN | chr19 | 42893191 | - |
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FusionProtFeatures for GSK3A_CNFN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GSK3A | CNFN |