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Fusion gene ID: 15484

FusionGeneSummary for GRN_HIPK1

Fusion gene summary

Fusion gene information	Fusion gene name: GRN_HIPK1
	Fusion gene ID: 15484
		Hgene	Tgene
	Gene symbol	GRN	HIPK1
	Gene ID	2896	204851
	Gene name	granulin precursor	homeodomain interacting protein kinase 1
	Synonyms	CLN11\|GEP\|GP88\|PCDGF\|PEPI\|PGRN	Myak\|Nbak2
	Cytomap	17q21.31	1p13.2
	Type of gene	protein-coding	protein-coding
	Description	granulinsPC cell-derived growth factoracrograningranulin-epithelinproepithelinprogranulin	homeodomain-interacting protein kinase 1homeodomain interacting protein kinase 1-like proteinnuclear body associated kinase 2bnuclear body-associated kinase 2
	Modification date	20180522	20180519
	UniProtAcc	P28799	Q86Z02
	Ensembl transtripts involved in fusion gene	ENST00000053867, ENST00000589265, ENST00000589923,	ENST00000426820, ENST00000369559, ENST00000369554, ENST00000369558, ENST00000369561, ENST00000369555, ENST00000340480, ENST00000369553, ENST00000406344,
Fusion gene scores	* DoF score	13 X 10 X 6=780	2 X 2 X 1=4
	# samples	19	3
	** MAII score	log2(19/780*10)=-2.03747470541866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/4*10)=2.90689059560852
Context	PubMed: GRN [Title/Abstract] AND HIPK1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HIPK1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	15701637
Tgene	HIPK1	GO:0072577	endothelial cell apoptotic process	15701637
Tgene	HIPK1	GO:0097191	extrinsic apoptotic signaling pathway	15701637

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW841772	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
ChiTaRS3.1			AW841754	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000053867	ENST00000426820	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000053867	ENST00000369559	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000053867	ENST00000369554	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000053867	ENST00000369558	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000053867	ENST00000369561	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000053867	ENST00000369555	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000053867	ENST00000340480	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000053867	ENST00000369553	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000053867	ENST00000406344	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000589265	ENST00000426820	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000589265	ENST00000369559	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000589265	ENST00000369554	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000589265	ENST00000369558	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000589265	ENST00000369561	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000589265	ENST00000369555	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000589265	ENST00000340480	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-intron	ENST00000589265	ENST00000369553	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
5CDS-3UTR	ENST00000589265	ENST00000406344	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-intron	ENST00000589923	ENST00000426820	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-intron	ENST00000589923	ENST00000369559	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-3UTR	ENST00000589923	ENST00000369554	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-3UTR	ENST00000589923	ENST00000369558	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-intron	ENST00000589923	ENST00000369561	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-intron	ENST00000589923	ENST00000369555	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-3UTR	ENST00000589923	ENST00000340480	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-intron	ENST00000589923	ENST00000369553	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-
3UTR-3UTR	ENST00000589923	ENST00000406344	GRN	chr17	42429040	-	HIPK1	chr1	114518412	-

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FusionProtFeatures for GRN_HIPK1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRN P28799	HIPK1 Q86Z02

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Fusion gene ID: 15484

FusionGeneSummary for GRN_HIPK1

FusionProtFeatures for GRN_HIPK1