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Fusion gene ID: 15468 |
FusionGeneSummary for GRM1_CNOT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRM1_CNOT2 | Fusion gene ID: 15468 | Hgene | Tgene | Gene symbol | GRM1 | CNOT2 | Gene ID | 2911 | 4848 |
| Gene name | glutamate metabotropic receptor 1 | CCR4-NOT transcription complex subunit 2 | |
| Synonyms | GPRC1A|MGLU1|MGLUR1|PPP1R85|SCA44|SCAR13 | CDC36|HSPC131|NOT2|NOT2H | |
| Cytomap | 6q24.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metabotropic glutamate receptor 1glutamate receptor, metabotropic 1protein phosphatase 1, regulatory subunit 85 | CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13255 | Q9NZN8 | |
| Ensembl transtripts involved in fusion gene | ENST00000361719, ENST00000392299, ENST00000492807, ENST00000355289, ENST00000282753, ENST00000507907, | ENST00000229195, ENST00000418359, ENST00000548230, ENST00000551483, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 14 X 9 X 5=630 |
| # samples | 1 | 11 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRM1 [Title/Abstract] AND CNOT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRM1 | GO:0007186 | G-protein coupled receptor signaling pathway | 24603153 |
| Hgene | GRM1 | GO:0038042 | dimeric G-protein coupled receptor signaling pathway | 24603153 |
| Tgene | CNOT2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14707134|16712523 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A3U5-01A | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000361719 | ENST00000229195 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000361719 | ENST00000418359 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000361719 | ENST00000548230 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000361719 | ENST00000551483 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000392299 | ENST00000229195 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000392299 | ENST00000418359 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000392299 | ENST00000548230 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000392299 | ENST00000551483 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000492807 | ENST00000229195 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000492807 | ENST00000418359 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000492807 | ENST00000548230 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000492807 | ENST00000551483 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000355289 | ENST00000229195 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000355289 | ENST00000418359 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000355289 | ENST00000548230 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000355289 | ENST00000551483 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000282753 | ENST00000229195 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000282753 | ENST00000418359 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000282753 | ENST00000548230 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000282753 | ENST00000551483 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000507907 | ENST00000229195 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| Frame-shift | ENST00000507907 | ENST00000418359 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000507907 | ENST00000548230 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
| 5CDS-intron | ENST00000507907 | ENST00000551483 | GRM1 | chr6 | 146720835 | + | CNOT2 | chr12 | 70713078 | + |
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FusionProtFeatures for GRM1_CNOT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRM1 | CNOT2 |