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Fusion gene ID: 15464 |
FusionGeneSummary for GRK5_SUMF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRK5_SUMF1 | Fusion gene ID: 15464 | Hgene | Tgene | Gene symbol | GRK5 | SUMF1 | Gene ID | 2869 | 285362 |
| Gene name | G protein-coupled receptor kinase 5 | sulfatase modifying factor 1 | |
| Synonyms | GPRK5 | AAPA3037|FGE|UNQ3037 | |
| Cytomap | 10q26.11 | 3p26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | G protein-coupled receptor kinase 5FP2025g protein-coupled receptor kinase GRK5 | sulfatase-modifying factor 1C-alpha-formylglycine-generating enzyme 1FGly-generating enzyme | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P34947 | Q8NBK3 | |
| Ensembl transtripts involved in fusion gene | ENST00000392870, ENST00000369108, ENST00000473264, | ENST00000534863, ENST00000470751, ENST00000272902, ENST00000383843, ENST00000458465, ENST00000405420, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 5 X 4 X 4=80 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRK5 [Title/Abstract] AND SUMF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRK5 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
| Hgene | GRK5 | GO:0043066 | negative regulation of apoptotic process | 20124405 |
| Hgene | GRK5 | GO:0046777 | protein autophosphorylation | 14976207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A48R-01A | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000392870 | ENST00000534863 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000392870 | ENST00000470751 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000392870 | ENST00000272902 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000392870 | ENST00000383843 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000392870 | ENST00000458465 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000392870 | ENST00000405420 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| In-frame | ENST00000369108 | ENST00000534863 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000369108 | ENST00000470751 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000369108 | ENST00000272902 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000369108 | ENST00000383843 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000369108 | ENST00000458465 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| 5CDS-intron | ENST00000369108 | ENST00000405420 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| intron-3CDS | ENST00000473264 | ENST00000534863 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| intron-intron | ENST00000473264 | ENST00000470751 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| intron-intron | ENST00000473264 | ENST00000272902 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| intron-intron | ENST00000473264 | ENST00000383843 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| intron-intron | ENST00000473264 | ENST00000458465 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
| intron-intron | ENST00000473264 | ENST00000405420 | GRK5 | chr10 | 121191039 | + | SUMF1 | chr3 | 4110429 | - |
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FusionProtFeatures for GRK5_SUMF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRK5 | SUMF1 |