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Fusion gene ID: 15459 |
FusionGeneSummary for GRK4_GRK4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRK4_GRK4 | Fusion gene ID: 15459 | Hgene | Tgene | Gene symbol | GRK4 | GRK4 | Gene ID | 2868 | 2868 |
| Gene name | G protein-coupled receptor kinase 4 | G protein-coupled receptor kinase 4 | |
| Synonyms | GPRK2L|GPRK4|GRK4a|IT11 | GPRK2L|GPRK4|GRK4a|IT11 | |
| Cytomap | 4p16.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | G protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-like | G protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-like | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P32298 | P32298 | |
| Ensembl transtripts involved in fusion gene | ENST00000398051, ENST00000398052, ENST00000504933, ENST00000345167, ENST00000503518, ENST00000442472, ENST00000509545, | ENST00000398051, ENST00000398052, ENST00000504933, ENST00000345167, ENST00000503518, ENST00000442472, ENST00000509545, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 7 X 6=168 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRK4 [Title/Abstract] AND GRK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRK4 | GO:0031623 | receptor internalization | 20074556 |
| Tgene | GRK4 | GO:0031623 | receptor internalization | 20074556 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF329649 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000398051 | ENST00000398051 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398051 | ENST00000398052 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398051 | ENST00000504933 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398051 | ENST00000345167 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398051 | ENST00000503518 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398051 | ENST00000442472 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398051 | ENST00000509545 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398052 | ENST00000398051 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398052 | ENST00000398052 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398052 | ENST00000504933 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398052 | ENST00000345167 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398052 | ENST00000503518 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398052 | ENST00000442472 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000398052 | ENST00000509545 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000504933 | ENST00000398051 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000504933 | ENST00000398052 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000504933 | ENST00000504933 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000504933 | ENST00000345167 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000504933 | ENST00000503518 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000504933 | ENST00000442472 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000504933 | ENST00000509545 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000345167 | ENST00000398051 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000345167 | ENST00000398052 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000345167 | ENST00000504933 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000345167 | ENST00000345167 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000345167 | ENST00000503518 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000345167 | ENST00000442472 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000345167 | ENST00000509545 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000503518 | ENST00000398051 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000503518 | ENST00000398052 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000503518 | ENST00000504933 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000503518 | ENST00000345167 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000503518 | ENST00000503518 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000503518 | ENST00000442472 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000503518 | ENST00000509545 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000442472 | ENST00000398051 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000442472 | ENST00000398052 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000442472 | ENST00000504933 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000442472 | ENST00000345167 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000442472 | ENST00000503518 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000442472 | ENST00000442472 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000442472 | ENST00000509545 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000509545 | ENST00000398051 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000509545 | ENST00000398052 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000509545 | ENST00000504933 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000509545 | ENST00000345167 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000509545 | ENST00000503518 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000509545 | ENST00000442472 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
| intron-intron | ENST00000509545 | ENST00000509545 | GRK4 | chr4 | 3023248 | + | GRK4 | chr4 | 3023346 | - |
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FusionProtFeatures for GRK4_GRK4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRK4 | GRK4 |