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Fusion gene ID: 15428

FusionGeneSummary for GRIK2_GPC1

Fusion gene summary

Fusion gene information	Fusion gene name: GRIK2_GPC1
	Fusion gene ID: 15428
		Hgene	Tgene
	Gene symbol	GRIK2	GPC1
	Gene ID	2901	2817
	Gene name	glutamate ionotropic receptor kainate type subunit 5	glypican 1
	Synonyms	EAA2\|GRIK2\|GluK5\|KA2	glypican
	Cytomap	19q13.2	2q37.3
	Type of gene	protein-coding	protein-coding
	Description	glutamate receptor ionotropic, kainate 5excitatory amino acid receptor 2glutamate receptor KA2	glypican-1glypican proteoglycan 1
	Modification date	20180523	20180522
	UniProtAcc	Q13002	P35052
	Ensembl transtripts involved in fusion gene	ENST00000413795, ENST00000369138, ENST00000421544, ENST00000358361, ENST00000318991, ENST00000369137, ENST00000369134,	ENST00000264039, ENST00000466624,
Fusion gene scores	* DoF score	7 X 3 X 4=84	2 X 2 X 2=8
	# samples	6	2
	** MAII score	log2(6/84*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: GRIK2 [Title/Abstract] AND GPC1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GPC1	GO:0030200	heparan sulfate proteoglycan catabolic process	12732622

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-D3-A2JP-06A	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000413795	ENST00000264039	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
5CDS-intron	ENST00000413795	ENST00000466624	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
In-frame	ENST00000369138	ENST00000264039	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
5CDS-intron	ENST00000369138	ENST00000466624	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
In-frame	ENST00000421544	ENST00000264039	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
5CDS-intron	ENST00000421544	ENST00000466624	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
In-frame	ENST00000358361	ENST00000264039	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
5CDS-intron	ENST00000358361	ENST00000466624	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
In-frame	ENST00000318991	ENST00000264039	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
5CDS-intron	ENST00000318991	ENST00000466624	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
In-frame	ENST00000369137	ENST00000264039	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
5CDS-intron	ENST00000369137	ENST00000466624	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
intron-3CDS	ENST00000369134	ENST00000264039	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+
intron-intron	ENST00000369134	ENST00000466624	GRIK2	chr6	101847268	+	GPC1	chr2	241398447	+

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FusionProtFeatures for GRIK2_GPC1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRIK2 Q13002	GPC1 P35052

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Fusion gene ID: 15428

FusionGeneSummary for GRIK2_GPC1

FusionProtFeatures for GRIK2_GPC1