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Fusion gene ID: 15423 |
FusionGeneSummary for GRID2_PRDX6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRID2_PRDX6 | Fusion gene ID: 15423 | Hgene | Tgene | Gene symbol | GRID2 | PRDX6 | Gene ID | 2895 | 25824 |
| Gene name | glutamate ionotropic receptor delta type subunit 2 | peroxiredoxin 5 | |
| Synonyms | GluD2|SCAR18 | ACR1|AOEB166|B166|HEL-S-55|PLP|PMP20|PRDX6|PRXV|SBBI10|prx-V | |
| Cytomap | 4q22.1-q22.2 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate receptor ionotropic, delta-2gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor, ionotropic, delta 2 | peroxiredoxin-5, mitochondrialAlu co-repressor 1TPx type VIantioxidant enzyme B166epididymis secretory protein Li 55liver tissue 2D-page spot 71Bperoxiredoxin Vperoxisomal antioxidant enzymethioredoxin peroxidase PMP20thioredoxin reductase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43424 | P30041 | |
| Ensembl transtripts involved in fusion gene | ENST00000282020, ENST00000505687, ENST00000510992, | ENST00000340385, ENST00000470017, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 1=9 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GRID2 [Title/Abstract] AND PRDX6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRDX6 | GO:0006979 | response to oxidative stress | 10521424 |
| Tgene | PRDX6 | GO:0016480 | negative regulation of transcription by RNA polymerase III | 10095767 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF972933 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000282020 | ENST00000340385 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3UTR | ENST00000282020 | ENST00000470017 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3CDS | ENST00000505687 | ENST00000340385 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3UTR | ENST00000505687 | ENST00000470017 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3CDS | ENST00000510992 | ENST00000340385 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3UTR | ENST00000510992 | ENST00000470017 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
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FusionProtFeatures for GRID2_PRDX6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRID2 | PRDX6 |