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Fusion gene ID: 15415 |
FusionGeneSummary for GRIA3_PHF20 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRIA3_PHF20 | Fusion gene ID: 15415 | Hgene | Tgene | Gene symbol | GRIA3 | PHF20 | Gene ID | 2892 | 51230 |
| Gene name | glutamate ionotropic receptor AMPA type subunit 3 | PHD finger protein 20 | |
| Synonyms | GLUR-C|GLUR-K3|GLUR3|GLURC|GluA3|MRX94 | C20orf104|GLEA2|HCA58|NZF|TDRD20A|TZP | |
| Cytomap | Xq25 | 20q11.22-q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate receptor 3AMPA-selective glutamate receptor 3dJ1171F9.1gluR-3glutamate receptor Cglutamate receptor subunit 3glutamate receptor, ionotrophic, AMPA 3glutamate receptor, ionotropic, AMPA 3 | PHD finger protein 20glioma-expressed antigen 2hepatocellular carcinoma-associated antigen 58novel zinc finger proteintranscription factor TZPtudor domain containing 20A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P42263 | Q9BVI0 | |
| Ensembl transtripts involved in fusion gene | ENST00000264357, ENST00000542149, ENST00000371251, ENST00000371256, ENST00000541091, ENST00000371266, ENST00000371264, ENST00000479118, | ENST00000374012, ENST00000439301, ENST00000481202, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 9 X 9=810 |
| # samples | 1 | 14 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(14/810*10)=-2.53249508082702 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRIA3 [Title/Abstract] AND PHF20 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PHF20 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Tgene | PHF20 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Tgene | PHF20 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | X82068 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000264357 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| 3UTR-3UTR | ENST00000264357 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| 3UTR-intron | ENST00000264357 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000542149 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000542149 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-intron | ENST00000542149 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000371251 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000371251 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-intron | ENST00000371251 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| 3UTR-3UTR | ENST00000371256 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| 3UTR-3UTR | ENST00000371256 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| 3UTR-intron | ENST00000371256 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000541091 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000541091 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-intron | ENST00000541091 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000371266 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000371266 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-intron | ENST00000371266 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000371264 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000371264 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-intron | ENST00000371264 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000479118 | ENST00000374012 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-3UTR | ENST00000479118 | ENST00000439301 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
| intron-intron | ENST00000479118 | ENST00000481202 | GRIA3 | chrX | 122622610 | + | PHF20 | chr20 | 34537177 | + |
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FusionProtFeatures for GRIA3_PHF20 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRIA3 | PHF20 |