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Fusion gene ID: 15409 |
FusionGeneSummary for GRHPR_GATA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRHPR_GATA3 | Fusion gene ID: 15409 | Hgene | Tgene | Gene symbol | GRHPR | GATA3 | Gene ID | 9380 | 2625 |
| Gene name | glyoxylate and hydroxypyruvate reductase | GATA binding protein 3 | |
| Synonyms | GLXR|GLYD|PH2 | HDR|HDRS | |
| Cytomap | 9p13.2 | 10p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glyoxylate reductase/hydroxypyruvate reductaseglycerate-2-dehydrogenaseglyoxylate reductase and hydroxypyruvate reductase | trans-acting T-cell-specific transcription factor GATA-3GATA-binding factor 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UBQ7 | P23771 | |
| Ensembl transtripts involved in fusion gene | ENST00000493368, ENST00000318158, ENST00000607784, | ENST00000379328, ENST00000346208, ENST00000461472, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GRHPR [Title/Abstract] AND GATA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRHPR | GO:0046487 | glyoxylate metabolic process | 10524214 |
| Hgene | GRHPR | GO:0051259 | protein complex oligomerization | 16756993 |
| Hgene | GRHPR | GO:0055114 | oxidation-reduction process | 10484776|10524214 |
| Tgene | GATA3 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 19483726 |
| Tgene | GATA3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19723756|19805038 |
| Tgene | GATA3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19232384|20189993|20484083 |
| Tgene | GATA3 | GO:0060231 | mesenchymal to epithelial transition | 20189993 |
| Tgene | GATA3 | GO:0072676 | lymphocyte migration | 19805038 |
| Tgene | GATA3 | GO:2000664 | positive regulation of interleukin-5 secretion | 20554961 |
| Tgene | GATA3 | GO:2000667 | positive regulation of interleukin-13 secretion | 20554961 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A12A-01A | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000493368 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| intron-3CDS | ENST00000493368 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| intron-3UTR | ENST00000493368 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000318158 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000318158 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| 5CDS-3UTR | ENST00000318158 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000607784 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000607784 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| 5CDS-3UTR | ENST00000607784 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
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FusionProtFeatures for GRHPR_GATA3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRHPR | GATA3 |