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Fusion gene ID: 15389 |
FusionGeneSummary for GRHL2_CRMP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRHL2_CRMP1 | Fusion gene ID: 15389 | Hgene | Tgene | Gene symbol | GRHL2 | CRMP1 | Gene ID | 79977 | 1400 |
| Gene name | grainyhead like transcription factor 2 | collapsin response mediator protein 1 | |
| Synonyms | BOM|DFNA28|ECTDS|TFCP2L3 | CRMP-1|DPYSL1|DRP-1|DRP1|ULIP-3 | |
| Cytomap | 8q22.3 | 4p16.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | grainyhead-like protein 2 homologbrother of mammalian grainyheadgrainyhead-like 2transcription factor CP2-like 3 | dihydropyrimidinase-related protein 1dihydropyrimidinase-like 1unc-33-like phosphoprotein 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6ISB3 | Q14194 | |
| Ensembl transtripts involved in fusion gene | ENST00000251808, ENST00000395927, ENST00000517674, | ENST00000324989, ENST00000397890, ENST00000511535, ENST00000512574, | |
| Fusion gene scores | * DoF score | 23 X 10 X 9=2070 | 6 X 6 X 4=144 |
| # samples | 20 | 6 | |
| ** MAII score | log2(20/2070*10)=-3.37155886261196 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRHL2 [Title/Abstract] AND CRMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRHL2 | GO:0008544 | epidermis development | 23254293 |
| Hgene | GRHL2 | GO:0044030 | regulation of DNA methylation | 23254293 |
| Hgene | GRHL2 | GO:0045617 | negative regulation of keratinocyte differentiation | 23254293 |
| Hgene | GRHL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23814079 |
| Tgene | CRMP1 | GO:1904530 | negative regulation of actin filament binding | 25358863 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-IQ-A61H-01A | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000251808 | ENST00000324989 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| Frame-shift | ENST00000251808 | ENST00000397890 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| 5CDS-5UTR | ENST00000251808 | ENST00000511535 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| 5CDS-5UTR | ENST00000251808 | ENST00000512574 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| 5UTR-3CDS | ENST00000395927 | ENST00000324989 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| 5UTR-3CDS | ENST00000395927 | ENST00000397890 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| 5UTR-5UTR | ENST00000395927 | ENST00000511535 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| 5UTR-5UTR | ENST00000395927 | ENST00000512574 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| intron-3CDS | ENST00000517674 | ENST00000324989 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| intron-3CDS | ENST00000517674 | ENST00000397890 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| intron-5UTR | ENST00000517674 | ENST00000511535 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
| intron-5UTR | ENST00000517674 | ENST00000512574 | GRHL2 | chr8 | 102505017 | + | CRMP1 | chr4 | 5830395 | - |
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FusionProtFeatures for GRHL2_CRMP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRHL2 | CRMP1 |