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Fusion gene ID: 15300 |
FusionGeneSummary for GPRC5A_XRN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPRC5A_XRN2 | Fusion gene ID: 15300 | Hgene | Tgene | Gene symbol | GPRC5A | XRN2 | Gene ID | 9052 | 22803 |
| Gene name | G protein-coupled receptor class C group 5 member A | 5'-3' exoribonuclease 2 | |
| Synonyms | GPCR5A|PEIG-1|RAI3|RAIG1|TIG1 | - | |
| Cytomap | 12p13.1 | 20p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | retinoic acid-induced protein 3G-protein coupled receptor family C group 5 member ATPA induced gene 1orphan G-protein-coupling receptor PEIG-1phorbol ester induced gene 1phorbol ester induced protein-1retinoic acid induced 3retinoic acid responsive | 5'-3' exoribonuclease 2DHP proteinDhm1-like protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q8NFJ5 | Q9H0D6 | |
| Ensembl transtripts involved in fusion gene | ENST00000014914, ENST00000542056, | ENST00000377191, ENST00000430571, ENST00000539513, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 1=16 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GPRC5A [Title/Abstract] AND XRN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | XRN2 | GO:0000738 | DNA catabolic process, exonucleolytic | 15565158 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI917076 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000014914 | ENST00000377191 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| 3UTR-intron | ENST00000014914 | ENST00000430571 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| 3UTR-intron | ENST00000014914 | ENST00000539513 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| intron-intron | ENST00000542056 | ENST00000377191 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| intron-intron | ENST00000542056 | ENST00000430571 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
| intron-intron | ENST00000542056 | ENST00000539513 | GPRC5A | chr12 | 13066290 | - | XRN2 | chr20 | 21322677 | - |
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FusionProtFeatures for GPRC5A_XRN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPRC5A | XRN2 |