|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 15283 |
FusionGeneSummary for GPR37L1_ELF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPR37L1_ELF3 | Fusion gene ID: 15283 | Hgene | Tgene | Gene symbol | GPR37L1 | ELF3 | Gene ID | 9283 | 1999 |
| Gene name | G protein-coupled receptor 37 like 1 | E74 like ETS transcription factor 3 | |
| Synonyms | ET(B)R-LP-2|ETBR-LP-2|ETBRLP2 | EPR-1|ERT|ESE-1|ESX | |
| Cytomap | 1q32.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prosaposin receptor GPR37L1endothelin B receptor-like protein 2endothelin type b receptor-like protein 2 | ETS-related transcription factor Elf-3E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)E74-like factor 3 (ets domain transcription factor)E74-like factor 3 (ets domain transcription factor, epithelial-specific )epith | |
| Modification date | 20180520 | 20180523 | |
| UniProtAcc | O60883 | P78545 | |
| Ensembl transtripts involved in fusion gene | ENST00000367282, | ENST00000359651, ENST00000367284, ENST00000367283, ENST00000495848, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 6 X 3=126 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPR37L1 [Title/Abstract] AND ELF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GPR37L1 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 23690594 |
| Hgene | GPR37L1 | GO:0043410 | positive regulation of MAPK cascade | 23690594 |
| Tgene | ELF3 | GO:0045892 | negative regulation of transcription, DNA-templated | 10773884 |
| Tgene | ELF3 | GO:0045893 | positive regulation of transcription, DNA-templated | 9234700 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A94O-01A | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000367282 | ENST00000359651 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| 5CDS-3UTR | ENST00000367282 | ENST00000367284 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| 5CDS-3UTR | ENST00000367282 | ENST00000367283 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| 5CDS-intron | ENST00000367282 | ENST00000495848 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
Top |
FusionProtFeatures for GPR37L1_ELF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPR37L1 | ELF3 |