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Fusion gene ID: 15237

FusionGeneSummary for GPNMB_KLHL7

Fusion gene summary

Fusion gene information	Fusion gene name: GPNMB_KLHL7
	Fusion gene ID: 15237
		Hgene	Tgene
	Gene symbol	GPNMB	KLHL7
	Gene ID	10457	55975
	Gene name	glycoprotein nmb	kelch like family member 7
	Synonyms	HGFIN\|NMB\|PLCA3	CISS3\|KLHL6\|SBBI26
	Cytomap	7p15.3	7p15.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane glycoprotein NMBglycoprotein (transmembrane) nmbglycoprotein nmb-like proteinglycoprotein nonmetastatic melanoma protein Bhematopoietic growth factor inducible neurokinin-1osteoactivintransmembrane glycoprotein HGFIN	kelch-like protein 7kelch-like 6kelch-like 7kelch/BTB
	Modification date	20180523	20180522
	UniProtAcc	Q14956	Q8IXQ5
	Ensembl transtripts involved in fusion gene	ENST00000258733, ENST00000381990, ENST00000409458, ENST00000539136, ENST00000453162, ENST00000478451,	ENST00000322231, ENST00000339077, ENST00000539124, ENST00000542558, ENST00000409689, ENST00000545443, ENST00000479288, ENST00000322275, ENST00000410047, ENST00000545771,
Fusion gene scores	* DoF score	4 X 3 X 4=48	3 X 2 X 3=18
	# samples	4	3
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GPNMB [Title/Abstract] AND KLHL7 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GPNMB	GO:0001818	negative regulation of cytokine production	19350579
Hgene	GPNMB	GO:0001934	positive regulation of protein phosphorylation	22891158
Hgene	GPNMB	GO:0030335	positive regulation of cell migration	20711474
Hgene	GPNMB	GO:0031954	positive regulation of protein autophosphorylation	19350579
Hgene	GPNMB	GO:0034103	regulation of tissue remodeling	25010402
Hgene	GPNMB	GO:0042130	negative regulation of T cell proliferation	19350579
Hgene	GPNMB	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	19350579
Tgene	KLHL7	GO:0016567	protein ubiquitination	21828050

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	CESC	TCGA-DS-A7WI-01A	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000258733	ENST00000322231	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000339077	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000539124	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000542558	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000409689	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000545443	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000479288	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000322275	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000410047	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000258733	ENST00000545771	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000322231	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000339077	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000539124	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000542558	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000409689	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000545443	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000479288	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000322275	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000410047	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000381990	ENST00000545771	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000322231	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000339077	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000539124	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000542558	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000409689	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000545443	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000479288	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000322275	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000410047	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000409458	ENST00000545771	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000322231	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000339077	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000539124	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000542558	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000409689	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000545443	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000479288	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000322275	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000410047	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000539136	ENST00000545771	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000322231	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000339077	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000539124	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000542558	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000409689	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000545443	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000479288	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000322275	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000410047	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
5CDS-intron	ENST00000453162	ENST00000545771	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000322231	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000339077	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000539124	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000542558	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000409689	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000545443	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000479288	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000322275	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000410047	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+
intron-intron	ENST00000478451	ENST00000545771	GPNMB	chr7	23293931	+	KLHL7	chr7	23195610	+

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FusionProtFeatures for GPNMB_KLHL7

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPNMB Q14956	KLHL7 Q8IXQ5

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Fusion gene ID: 15237

FusionGeneSummary for GPNMB_KLHL7

FusionProtFeatures for GPNMB_KLHL7