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Fusion gene ID: 15224 |
FusionGeneSummary for GPM6A_ANKRD17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPM6A_ANKRD17 | Fusion gene ID: 15224 | Hgene | Tgene | Gene symbol | GPM6A | ANKRD17 | Gene ID | 2823 | 26057 |
| Gene name | glycoprotein M6A | ankyrin repeat domain 17 | |
| Synonyms | GPM6|M6A | GTAR|MASK2|NY-BR-16 | |
| Cytomap | 4q34.2 | 4q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuronal membrane glycoprotein M6-a | ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P51674 | O75179 | |
| Ensembl transtripts involved in fusion gene | ENST00000280187, ENST00000393658, ENST00000506894, ENST00000515090, ENST00000506219, | ENST00000358602, ENST00000509867, ENST00000330838, ENST00000514252, | |
| Fusion gene scores | * DoF score | 5 X 6 X 1=30 | 8 X 14 X 3=336 |
| # samples | 6 | 18 | |
| ** MAII score | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/336*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPM6A [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GPM6A | GO:0001764 | neuron migration | 19298174 |
| Hgene | GPM6A | GO:0048863 | stem cell differentiation | 19298174 |
| Tgene | ANKRD17 | GO:0042742 | defense response to bacterium | 23711367 |
| Tgene | ANKRD17 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22328336 |
| Tgene | ANKRD17 | GO:0045087 | innate immune response | 23711367 |
| Tgene | ANKRD17 | GO:1900245 | positive regulation of MDA-5 signaling pathway | 22328336 |
| Tgene | ANKRD17 | GO:1900246 | positive regulation of RIG-I signaling pathway | 22328336 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA350181 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - | ||
| ChiTaRS3.1 | AW957350 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000280187 | ENST00000358602 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000280187 | ENST00000509867 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000280187 | ENST00000330838 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000280187 | ENST00000514252 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000393658 | ENST00000358602 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000393658 | ENST00000509867 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000393658 | ENST00000330838 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000393658 | ENST00000514252 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506894 | ENST00000358602 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506894 | ENST00000509867 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000506894 | ENST00000330838 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000506894 | ENST00000514252 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000515090 | ENST00000358602 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000515090 | ENST00000509867 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000515090 | ENST00000330838 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000515090 | ENST00000514252 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506219 | ENST00000358602 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506219 | ENST00000509867 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000506219 | ENST00000330838 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000506219 | ENST00000514252 | GPM6A | chr4 | 176561295 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000280187 | ENST00000358602 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000280187 | ENST00000509867 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000280187 | ENST00000330838 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000280187 | ENST00000514252 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000393658 | ENST00000358602 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000393658 | ENST00000509867 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000393658 | ENST00000330838 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000393658 | ENST00000514252 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506894 | ENST00000358602 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506894 | ENST00000509867 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000506894 | ENST00000330838 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000506894 | ENST00000514252 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000515090 | ENST00000358602 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000515090 | ENST00000509867 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000515090 | ENST00000330838 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000515090 | ENST00000514252 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506219 | ENST00000358602 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-3CDS | ENST00000506219 | ENST00000509867 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-intron | ENST00000506219 | ENST00000330838 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
| intron-5UTR | ENST00000506219 | ENST00000514252 | GPM6A | chr4 | 176561299 | - | ANKRD17 | chr4 | 74005342 | - |
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FusionProtFeatures for GPM6A_ANKRD17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPM6A | ANKRD17 |