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Fusion gene ID: 15223 |
FusionGeneSummary for GPLD1_TDP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPLD1_TDP2 | Fusion gene ID: 15223 | Hgene | Tgene | Gene symbol | GPLD1 | TDP2 | Gene ID | 2822 | 51567 |
| Gene name | glycosylphosphatidylinositol specific phospholipase D1 | tyrosyl-DNA phosphodiesterase 2 | |
| Synonyms | GPIPLD|GPIPLDM|PIGPLD|PIGPLD1|PLD | AD022|EAP2|EAPII|TTRAP|dJ30M3.3|hTDP2 | |
| Cytomap | 6p22.3 | 6p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol-glycan-specific phospholipase DGPI-PLDGPI-specific phospholipase DPI-G PLDglycoprotein phospholipase D | tyrosyl-DNA phosphodiesterase 25'-Tyr-DNA phosphodiesterase5'-tyrosyl-DNA phosphodiesteraseETS1-associated protein 2ETS1-associated protein IITRAF and TNF receptor-associated proteinVPg unlinkasetyr-DNA phosphodiesterase 2tyrosyl-RNA phosphodieste | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P80108 | O95551 | |
| Ensembl transtripts involved in fusion gene | ENST00000230036, ENST00000474784, | ENST00000378198, ENST00000545995, ENST00000341060, ENST00000478285, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: GPLD1 [Title/Abstract] AND TDP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GPLD1 | GO:0002430 | complement receptor mediated signaling pathway | 15907827|19135435 |
| Hgene | GPLD1 | GO:0006507 | GPI anchor release | 2760042|15907827|19135435 |
| Hgene | GPLD1 | GO:0008285 | negative regulation of cell proliferation | 19135435 |
| Hgene | GPLD1 | GO:0008286 | insulin receptor signaling pathway | 18328347 |
| Hgene | GPLD1 | GO:0009749 | response to glucose | 15907827 |
| Hgene | GPLD1 | GO:0032869 | cellular response to insulin stimulus | 15907827 |
| Hgene | GPLD1 | GO:0035690 | cellular response to drug | 17761367 |
| Hgene | GPLD1 | GO:0043065 | positive regulation of apoptotic process | 19135435 |
| Hgene | GPLD1 | GO:0045919 | positive regulation of cytolysis | 15907827|19135435 |
| Hgene | GPLD1 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 17720976 |
| Hgene | GPLD1 | GO:0071277 | cellular response to calcium ion | 2760042 |
| Hgene | GPLD1 | GO:0071467 | cellular response to pH | 17761367 |
| Hgene | GPLD1 | GO:1900076 | regulation of cellular response to insulin stimulus | 18328347 |
| Tgene | TDP2 | GO:0006302 | double-strand break repair | 19794497 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-76-4929-01A | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000230036 | ENST00000378198 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| Frame-shift | ENST00000230036 | ENST00000545995 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| In-frame | ENST00000230036 | ENST00000341060 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| 5CDS-intron | ENST00000230036 | ENST00000478285 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-3CDS | ENST00000474784 | ENST00000378198 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-3CDS | ENST00000474784 | ENST00000545995 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-3CDS | ENST00000474784 | ENST00000341060 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-intron | ENST00000474784 | ENST00000478285 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
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FusionProtFeatures for GPLD1_TDP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPLD1 | TDP2 |