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Fusion gene ID: 15175 |
FusionGeneSummary for GPC3_PDGFRA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPC3_PDGFRA | Fusion gene ID: 15175 | Hgene | Tgene | Gene symbol | GPC3 | PDGFRA | Gene ID | 2719 | 5156 |
| Gene name | glypican 3 | platelet derived growth factor receptor alpha | |
| Synonyms | DGSX|GTR2-2|MXR7|OCI-5|SDYS|SGB|SGBS|SGBS1 | CD140A|PDGFR-2|PDGFR2 | |
| Cytomap | Xq26.2 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3 | platelet-derived growth factor receptor alphaCD140 antigen-like family member ACD140a antigenPDGF-R-alphaalpha-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 2platelet-derived growth factor receptor, alpha polype | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P51654 | P16234 | |
| Ensembl transtripts involved in fusion gene | ENST00000370818, ENST00000394299, ENST00000543339, | ENST00000257290, ENST00000508170, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 12 X 13 X 4=624 |
| # samples | 3 | 13 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/624*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPC3 [Title/Abstract] AND PDGFRA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDGFRA | GO:0008284 | positive regulation of cell proliferation | 10806482 |
| Tgene | PDGFRA | GO:0010544 | negative regulation of platelet activation | 8188664 |
| Tgene | PDGFRA | GO:0018108 | peptidyl-tyrosine phosphorylation | 1646396|2536956|8188664 |
| Tgene | PDGFRA | GO:0030335 | positive regulation of cell migration | 17470632 |
| Tgene | PDGFRA | GO:0034614 | cellular response to reactive oxygen species | 24190966 |
| Tgene | PDGFRA | GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | 17470632 |
| Tgene | PDGFRA | GO:0046777 | protein autophosphorylation | 1646396|2536956|8188664 |
| Tgene | PDGFRA | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 2536956|10806482 |
| Tgene | PDGFRA | GO:0048146 | positive regulation of fibroblast proliferation | 10806482 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI468457 | GPC3 | chrX | 132669971 | + | PDGFRA | chr4 | 55163459 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000370818 | ENST00000257290 | GPC3 | chrX | 132669971 | + | PDGFRA | chr4 | 55163459 | - |
| intron-intron | ENST00000370818 | ENST00000508170 | GPC3 | chrX | 132669971 | + | PDGFRA | chr4 | 55163459 | - |
| intron-3UTR | ENST00000394299 | ENST00000257290 | GPC3 | chrX | 132669971 | + | PDGFRA | chr4 | 55163459 | - |
| intron-intron | ENST00000394299 | ENST00000508170 | GPC3 | chrX | 132669971 | + | PDGFRA | chr4 | 55163459 | - |
| intron-3UTR | ENST00000543339 | ENST00000257290 | GPC3 | chrX | 132669971 | + | PDGFRA | chr4 | 55163459 | - |
| intron-intron | ENST00000543339 | ENST00000508170 | GPC3 | chrX | 132669971 | + | PDGFRA | chr4 | 55163459 | - |
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FusionProtFeatures for GPC3_PDGFRA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPC3 | PDGFRA |