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Fusion gene ID: 15126 |
FusionGeneSummary for GPA33_SOD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPA33_SOD1 | Fusion gene ID: 15126 | Hgene | Tgene | Gene symbol | GPA33 | SOD1 | Gene ID | 10223 | 6647 |
| Gene name | glycoprotein A33 | superoxide dismutase 1 | |
| Synonyms | A33 | ALS|ALS1|HEL-S-44|IPOA|SOD|hSod1|homodimer | |
| Cytomap | 1q24.1 | 21q22.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell surface A33 antigenglycoprotein A33 (transmembrane)transmembrane glycoprotein A33 | superoxide dismutase [Cu-Zn]Cu/Zn superoxide dismutaseSOD, solubleepididymis secretory protein Li 44indophenoloxidase Asuperoxide dismutase 1, solublesuperoxide dismutase, cystolic | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q99795 | P00441 | |
| Ensembl transtripts involved in fusion gene | ENST00000527955, ENST00000367868, | ENST00000270142, ENST00000389995, ENST00000470944, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: GPA33 [Title/Abstract] AND SOD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SOD1 | GO:0000303 | response to superoxide | 16790527 |
| Tgene | SOD1 | GO:0001819 | positive regulation of cytokine production | 15544046 |
| Tgene | SOD1 | GO:0006801 | superoxide metabolic process | 12551919 |
| Tgene | SOD1 | GO:0010033 | response to organic substance | 12921788 |
| Tgene | SOD1 | GO:0032930 | positive regulation of superoxide anion generation | 18219391 |
| Tgene | SOD1 | GO:0043085 | positive regulation of catalytic activity | 17324120 |
| Tgene | SOD1 | GO:0043087 | regulation of GTPase activity | 18219391 |
| Tgene | SOD1 | GO:0045541 | negative regulation of cholesterol biosynthetic process | 15473258 |
| Tgene | SOD1 | GO:0045859 | regulation of protein kinase activity | 16254550 |
| Tgene | SOD1 | GO:0050665 | hydrogen peroxide biosynthetic process | 15544046 |
| Tgene | SOD1 | GO:0060047 | heart contraction | 9539776 |
| Tgene | SOD1 | GO:0072593 | reactive oxygen species metabolic process | 24140062 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW376283 | GPA33 | chr1 | 167042668 | + | SOD1 | chr21 | 33039646 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000527955 | ENST00000270142 | GPA33 | chr1 | 167042668 | + | SOD1 | chr21 | 33039646 | - |
| intron-3CDS | ENST00000527955 | ENST00000389995 | GPA33 | chr1 | 167042668 | + | SOD1 | chr21 | 33039646 | - |
| intron-3UTR | ENST00000527955 | ENST00000470944 | GPA33 | chr1 | 167042668 | + | SOD1 | chr21 | 33039646 | - |
| intron-3CDS | ENST00000367868 | ENST00000270142 | GPA33 | chr1 | 167042668 | + | SOD1 | chr21 | 33039646 | - |
| intron-3CDS | ENST00000367868 | ENST00000389995 | GPA33 | chr1 | 167042668 | + | SOD1 | chr21 | 33039646 | - |
| intron-3UTR | ENST00000367868 | ENST00000470944 | GPA33 | chr1 | 167042668 | + | SOD1 | chr21 | 33039646 | - |
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FusionProtFeatures for GPA33_SOD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPA33 | SOD1 |