|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 1511 |
FusionGeneSummary for ALDOA_NDUFV1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALDOA_NDUFV1 | Fusion gene ID: 1511 | Hgene | Tgene | Gene symbol | ALDOA | NDUFV1 | Gene ID | 226 | 4723 |
| Gene name | aldolase, fructose-bisphosphate A | NADH:ubiquinone oxidoreductase core subunit V1 | |
| Synonyms | ALDA|GSD12|HEL-S-87p | CI-51K|CI51KD|UQOR1 | |
| Cytomap | 16p11.2 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDaNADH-ubiquinone oxidoreductase 51 kDa subunitcomplex I 51 kda subunitcomplex I 51kDa subunitcomplex I, mitochondrial respiratory chainm | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P04075 | P49821 | |
| Ensembl transtripts involved in fusion gene | ENST00000338110, ENST00000395248, ENST00000575627, ENST00000566897, ENST00000569545, ENST00000563060, ENST00000412304, ENST00000564546, ENST00000564595, ENST00000569798, ENST00000395240, | ENST00000322776, ENST00000532303, ENST00000529927, ENST00000415352, ENST00000526169, | |
| Fusion gene scores | * DoF score | 17 X 7 X 10=1190 | 35 X 6 X 14=2940 |
| # samples | 20 | 37 | |
| ** MAII score | log2(20/1190*10)=-2.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/2940*10)=-2.99021897920741 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALDOA [Title/Abstract] AND NDUFV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALDOA | GO:0008360 | regulation of cell shape | 9244396 |
| Hgene | ALDOA | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 9244396|14766013 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0CK-01A | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| TCGA | RV | PRAD | TCGA-KK-A8I6-01A | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000338110 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000338110 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000338110 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000338110 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000338110 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000395248 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000395248 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000395248 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000395248 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000395248 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000575627 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000575627 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000575627 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000575627 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000575627 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000566897 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000566897 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000566897 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000566897 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000566897 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569545 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569545 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569545 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569545 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569545 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000563060 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000563060 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000563060 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000563060 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000563060 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000412304 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000412304 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000412304 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000412304 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000412304 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000564546 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000564546 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000564546 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000564546 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 3UTR-intron | ENST00000564546 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000564595 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000564595 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000564595 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000564595 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| 5CDS-intron | ENST00000564595 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569798 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569798 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569798 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569798 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000569798 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000395240 | ENST00000322776 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000395240 | ENST00000532303 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000395240 | ENST00000529927 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000395240 | ENST00000415352 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
| intron-intron | ENST00000395240 | ENST00000526169 | ALDOA | chr16 | 30081734 | + | NDUFV1 | chr11 | 67375697 | + |
Top |
FusionProtFeatures for ALDOA_NDUFV1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALDOA | NDUFV1 |