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Fusion gene ID: 15042 |
FusionGeneSummary for GOLGA4_MLH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GOLGA4_MLH1 | Fusion gene ID: 15042 | Hgene | Tgene | Gene symbol | GOLGA4 | MLH1 | Gene ID | 2803 | 4292 |
| Gene name | golgin A4 | mutL homolog 1 | |
| Synonyms | CRPF46|GCP2|GOLG|MU-RMS-40.18|p230 | COCA2|FCC2|HNPCC|HNPCC2|hMLH1 | |
| Cytomap | 3p22.2 | 3p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | golgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230 | DNA mismatch repair protein Mlh1mutL homolog 1, colon cancer, nonpolyposis type 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q13439 | P40692 | |
| Ensembl transtripts involved in fusion gene | ENST00000361924, ENST00000435830, ENST00000444882, ENST00000356847, | ENST00000536378, ENST00000231790, ENST00000458205, ENST00000539477, ENST00000455445, ENST00000435176, ENST00000492474, | |
| Fusion gene scores | * DoF score | 12 X 10 X 6=720 | 6 X 7 X 3=126 |
| # samples | 13 | 8 | |
| ** MAII score | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GOLGA4 [Title/Abstract] AND MLH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GOLGA4 | GO:0043001 | Golgi to plasma membrane protein transport | 15265687 |
| Hgene | GOLGA4 | GO:0045773 | positive regulation of axon extension | 22705394 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-A46G-01A | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| TCGA | RV | STAD | TCGA-BR-A4QI-01A | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361924 | ENST00000536378 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000361924 | ENST00000231790 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000361924 | ENST00000458205 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000361924 | ENST00000539477 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000361924 | ENST00000455445 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000361924 | ENST00000435176 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 5CDS-intron | ENST00000361924 | ENST00000492474 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000536378 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000231790 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000458205 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000539477 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000455445 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000435176 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 3UTR-intron | ENST00000435830 | ENST00000492474 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| intron-3CDS | ENST00000444882 | ENST00000536378 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| intron-3CDS | ENST00000444882 | ENST00000231790 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| intron-3CDS | ENST00000444882 | ENST00000458205 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| intron-3CDS | ENST00000444882 | ENST00000539477 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| intron-3CDS | ENST00000444882 | ENST00000455445 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| intron-3CDS | ENST00000444882 | ENST00000435176 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| intron-intron | ENST00000444882 | ENST00000492474 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000356847 | ENST00000536378 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000356847 | ENST00000231790 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000356847 | ENST00000458205 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000356847 | ENST00000539477 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000356847 | ENST00000455445 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| In-frame | ENST00000356847 | ENST00000435176 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| 5CDS-intron | ENST00000356847 | ENST00000492474 | GOLGA4 | chr3 | 37343823 | + | MLH1 | chr3 | 37058997 | + |
| Frame-shift | ENST00000361924 | ENST00000536378 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000361924 | ENST00000231790 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000361924 | ENST00000458205 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000361924 | ENST00000539477 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000361924 | ENST00000455445 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000361924 | ENST00000435176 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 5CDS-intron | ENST00000361924 | ENST00000492474 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000536378 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000231790 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000458205 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000539477 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000455445 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 3UTR-3CDS | ENST00000435830 | ENST00000435176 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 3UTR-intron | ENST00000435830 | ENST00000492474 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| intron-3CDS | ENST00000444882 | ENST00000536378 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| intron-3CDS | ENST00000444882 | ENST00000231790 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| intron-3CDS | ENST00000444882 | ENST00000458205 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| intron-3CDS | ENST00000444882 | ENST00000539477 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| intron-3CDS | ENST00000444882 | ENST00000455445 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| intron-3CDS | ENST00000444882 | ENST00000435176 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| intron-intron | ENST00000444882 | ENST00000492474 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000356847 | ENST00000536378 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000356847 | ENST00000231790 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000356847 | ENST00000458205 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000356847 | ENST00000539477 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000356847 | ENST00000455445 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| Frame-shift | ENST00000356847 | ENST00000435176 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
| 5CDS-intron | ENST00000356847 | ENST00000492474 | GOLGA4 | chr3 | 37360685 | + | MLH1 | chr3 | 37061801 | + |
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FusionProtFeatures for GOLGA4_MLH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GOLGA4 | MLH1 |