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Fusion gene ID: 15041 |
FusionGeneSummary for GOLGA4_HSPA8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GOLGA4_HSPA8 | Fusion gene ID: 15041 | Hgene | Tgene | Gene symbol | GOLGA4 | HSPA8 | Gene ID | 2803 | 3312 |
| Gene name | golgin A4 | heat shock protein family A (Hsp70) member 8 | |
| Synonyms | CRPF46|GCP2|GOLG|MU-RMS-40.18|p230 | HEL-33|HEL-S-72p|HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP-1|LAP1|NIP71 | |
| Cytomap | 3p22.2 | 11q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | golgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230 | heat shock cognate 71 kDa proteinLPS-associated protein 1N-myristoyltransferase inhibitor protein 71constitutive heat shock protein 70epididymis luminal protein 33epididymis secretory sperm binding protein Li 72pheat shock 70kDa protein 8heat shock | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q13439 | P11142 | |
| Ensembl transtripts involved in fusion gene | ENST00000361924, ENST00000435830, ENST00000444882, ENST00000356847, | ENST00000532636, ENST00000533540, ENST00000453788, ENST00000534624, ENST00000227378, ENST00000534319, ENST00000526110, ENST00000526862, | |
| Fusion gene scores | * DoF score | 12 X 10 X 6=720 | 13 X 14 X 4=728 |
| # samples | 13 | 16 | |
| ** MAII score | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/728*10)=-2.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GOLGA4 [Title/Abstract] AND HSPA8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GOLGA4 | GO:0043001 | Golgi to plasma membrane protein transport | 15265687 |
| Hgene | GOLGA4 | GO:0045773 | positive regulation of axon extension | 22705394 |
| Tgene | HSPA8 | GO:0042026 | protein refolding | 21231916|25719862 |
| Tgene | HSPA8 | GO:0045892 | negative regulation of transcription, DNA-templated | 10722728 |
| Tgene | HSPA8 | GO:0046034 | ATP metabolic process | 23921388 |
| Tgene | HSPA8 | GO:1902904 | negative regulation of supramolecular fiber organization | 23921388 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-GM-A2DF-01A | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361924 | ENST00000532636 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000361924 | ENST00000533540 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000361924 | ENST00000453788 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000361924 | ENST00000534624 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000361924 | ENST00000227378 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-5UTR | ENST00000361924 | ENST00000534319 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000361924 | ENST00000526110 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000361924 | ENST00000526862 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-3CDS | ENST00000435830 | ENST00000532636 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-intron | ENST00000435830 | ENST00000533540 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-intron | ENST00000435830 | ENST00000453788 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-intron | ENST00000435830 | ENST00000534624 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-intron | ENST00000435830 | ENST00000227378 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-5UTR | ENST00000435830 | ENST00000534319 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-intron | ENST00000435830 | ENST00000526110 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| intron-intron | ENST00000435830 | ENST00000526862 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| In-frame | ENST00000444882 | ENST00000532636 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000444882 | ENST00000533540 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000444882 | ENST00000453788 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000444882 | ENST00000534624 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000444882 | ENST00000227378 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-5UTR | ENST00000444882 | ENST00000534319 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000444882 | ENST00000526110 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000444882 | ENST00000526862 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| In-frame | ENST00000356847 | ENST00000532636 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000356847 | ENST00000533540 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000356847 | ENST00000453788 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000356847 | ENST00000534624 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000356847 | ENST00000227378 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-5UTR | ENST00000356847 | ENST00000534319 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000356847 | ENST00000526110 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
| 5CDS-intron | ENST00000356847 | ENST00000526862 | GOLGA4 | chr3 | 37292975 | + | HSPA8 | chr11 | 122930976 | - |
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FusionProtFeatures for GOLGA4_HSPA8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GOLGA4 | HSPA8 |