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Fusion gene ID: 15009 |
FusionGeneSummary for GNS_FAM19A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNS_FAM19A2 | Fusion gene ID: 15009 | Hgene | Tgene | Gene symbol | GNS | FAM19A2 | Gene ID | 2799 | 338811 |
| Gene name | glucosamine (N-acetyl)-6-sulfatase | family with sequence similarity 19 member A2, C-C motif chemokine like | |
| Synonyms | G6S | TAFA-2|TAFA2 | |
| Cytomap | 12q14.3 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-acetylglucosamine-6-sulfataseglucosamine -6-sulfatase | protein FAM19A2chemokine-like protein TAFA-2family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P15586 | Q8N3H0 | |
| Ensembl transtripts involved in fusion gene | ENST00000418919, ENST00000258145, ENST00000543646, ENST00000542058, | ENST00000416284, ENST00000551619, ENST00000550003, ENST00000551449, ENST00000549456, | |
| Fusion gene scores | * DoF score | 9 X 7 X 5=315 | 11 X 6 X 5=330 |
| # samples | 8 | 10 | |
| ** MAII score | log2(8/315*10)=-1.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/330*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GNS [Title/Abstract] AND FAM19A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-GN-A26D-06A | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000418919 | ENST00000416284 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000418919 | ENST00000551619 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000418919 | ENST00000550003 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000418919 | ENST00000551449 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-5UTR | ENST00000418919 | ENST00000549456 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000258145 | ENST00000416284 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000258145 | ENST00000551619 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000258145 | ENST00000550003 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000258145 | ENST00000551449 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-5UTR | ENST00000258145 | ENST00000549456 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000543646 | ENST00000416284 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000543646 | ENST00000551619 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000543646 | ENST00000550003 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000543646 | ENST00000551449 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-5UTR | ENST00000543646 | ENST00000549456 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000542058 | ENST00000416284 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000542058 | ENST00000551619 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000542058 | ENST00000550003 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-intron | ENST00000542058 | ENST00000551449 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
| 5CDS-5UTR | ENST00000542058 | ENST00000549456 | GNS | chr12 | 65138589 | - | FAM19A2 | chr12 | 62601031 | - |
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FusionProtFeatures for GNS_FAM19A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNS | FAM19A2 |