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Fusion gene ID: 15000 |
FusionGeneSummary for GNPTAB_FGD6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNPTAB_FGD6 | Fusion gene ID: 15000 | Hgene | Tgene | Gene symbol | GNPTAB | FGD6 | Gene ID | 79158 | 55785 |
| Gene name | N-acetylglucosamine-1-phosphate transferase subunits alpha and beta | FYVE, RhoGEF and PH domain containing 6 | |
| Synonyms | GNPTA|ICD | ZFYVE24 | |
| Cytomap | 12q23.2 | 12q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-acetylglucosamine-1-phosphotransferase subunits alpha/betaGlcNAc phosphotransferaseN-acetylglucosamine-1-phosphate transferase alpha and beta subunitsUDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/betaUDP-N-acetylglucosamine-lysosomal-e | FYVE, RhoGEF and PH domain-containing protein 6zinc finger FYVE domain-containing protein 24 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q3T906 | Q6ZV73 | |
| Ensembl transtripts involved in fusion gene | ENST00000299314, ENST00000549940, ENST00000392919, ENST00000549165, | ENST00000343958, ENST00000546711, ENST00000549499, ENST00000550368, | |
| Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 4 X 4 X 2=32 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/256*10)=-1.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GNPTAB [Title/Abstract] AND FGD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GNPTAB | GO:0046835 | carbohydrate phosphorylation | 19955174|23733939 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A23V-01A | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000299314 | ENST00000343958 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| Frame-shift | ENST00000299314 | ENST00000546711 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| Frame-shift | ENST00000299314 | ENST00000549499 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| 5CDS-intron | ENST00000299314 | ENST00000550368 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000549940 | ENST00000343958 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000549940 | ENST00000546711 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000549940 | ENST00000549499 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-intron | ENST00000549940 | ENST00000550368 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000392919 | ENST00000343958 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000392919 | ENST00000546711 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000392919 | ENST00000549499 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-intron | ENST00000392919 | ENST00000550368 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000549165 | ENST00000343958 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000549165 | ENST00000546711 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-3CDS | ENST00000549165 | ENST00000549499 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
| intron-intron | ENST00000549165 | ENST00000550368 | GNPTAB | chr12 | 102142879 | - | FGD6 | chr12 | 95566520 | - |
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FusionProtFeatures for GNPTAB_FGD6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNPTAB | FGD6 |