|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 1498 |
FusionGeneSummary for ALDH9A1_PSAP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALDH9A1_PSAP | Fusion gene ID: 1498 | Hgene | Tgene | Gene symbol | ALDH9A1 | PSAP | Gene ID | 223 | 729238 |
| Gene name | aldehyde dehydrogenase 9 family member A1 | surfactant protein A2 | |
| Synonyms | ALDH4|ALDH7|ALDH9|E3|TMABADH | COLEC5|PSAP|PSP-A|PSPA|SFTP1|SFTPA2B|SP-2A|SP-A|SPA2|SPAII | |
| Cytomap | 1q24.1 | 10q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 4-trimethylaminobutyraldehyde dehydrogenaseR-aminobutyraldehyde dehydrogenasealdehyde dehydrogenase (NAD+)aldehyde dehydrogenase E3 isozymealdehyde dehydrogenase family 9 member A1gamma-aminobutyraldehyde dehydrogenase | pulmonary surfactant-associated protein A235 kDa pulmonary surfactant-associated proteinalveolar proteinosis proteincollectin 5surfactant, pulmonary-associated protein A2A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P49189 | P07602 | |
| Ensembl transtripts involved in fusion gene | ENST00000354775, ENST00000538148, ENST00000461664, | ENST00000394936, ENST00000394934, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 12 X 17 X 4=816 |
| # samples | 4 | 18 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/816*10)=-2.18057224564182 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALDH9A1 [Title/Abstract] AND PSAP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALDH9A1 | GO:0006081 | cellular aldehyde metabolic process | 8645224 |
| Hgene | ALDH9A1 | GO:0042136 | neurotransmitter biosynthetic process | 2925663 |
| Hgene | ALDH9A1 | GO:0055114 | oxidation-reduction process | 2925663 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP391559 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000354775 | ENST00000394936 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
| intron-3UTR | ENST00000354775 | ENST00000394934 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
| intron-3UTR | ENST00000538148 | ENST00000394936 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
| intron-3UTR | ENST00000538148 | ENST00000394934 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
| intron-3UTR | ENST00000461664 | ENST00000394936 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
| intron-3UTR | ENST00000461664 | ENST00000394934 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
Top |
FusionProtFeatures for ALDH9A1_PSAP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALDH9A1 | PSAP |