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Fusion gene ID: 14967 |
FusionGeneSummary for GNGT1_UBE2I |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNGT1_UBE2I | Fusion gene ID: 14967 | Hgene | Tgene | Gene symbol | GNGT1 | UBE2I | Gene ID | 2792 | 7329 |
| Gene name | G protein subunit gamma transducin 1 | ubiquitin conjugating enzyme E2 I | |
| Synonyms | GNG1 | C358B7.1|P18|UBC9 | |
| Cytomap | 7q21.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein G(T) subunit gamma-T1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1transducin gamma chain | SUMO-conjugating enzyme UBC9RING-type E3 SUMO transferase UBC9SUMO-1-protein ligaseSUMO-protein ligaseubiquitin carrier protein 9ubiquitin carrier protein Iubiquitin conjugating enzyme 9ubiquitin conjugating enzyme E2Iubiquitin-conjugating enzyme | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P63211 | P63279 | |
| Ensembl transtripts involved in fusion gene | ENST00000455502, ENST00000248572, ENST00000429473, ENST00000430875, ENST00000428834, | ENST00000339021, ENST00000355803, ENST00000325437, ENST00000397514, ENST00000397515, ENST00000403747, ENST00000566587, ENST00000406620, ENST00000402301, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 5 X 5=125 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GNGT1 [Title/Abstract] AND UBE2I [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | UBE2I | GO:0016925 | protein sumoylation | 15660128|19955185|21968017 |
| Tgene | UBE2I | GO:0045892 | negative regulation of transcription, DNA-templated | 16631117 |
| Tgene | UBE2I | GO:1903755 | positive regulation of SUMO transferase activity | 19955185 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW995893 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000455502 | ENST00000339021 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000455502 | ENST00000355803 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000455502 | ENST00000325437 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000455502 | ENST00000397514 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000455502 | ENST00000397515 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000455502 | ENST00000403747 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000455502 | ENST00000566587 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000455502 | ENST00000406620 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000455502 | ENST00000402301 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000248572 | ENST00000339021 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000248572 | ENST00000355803 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000248572 | ENST00000325437 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000248572 | ENST00000397514 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000248572 | ENST00000397515 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000248572 | ENST00000403747 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000248572 | ENST00000566587 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000248572 | ENST00000406620 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000248572 | ENST00000402301 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000429473 | ENST00000339021 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000429473 | ENST00000355803 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000429473 | ENST00000325437 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000429473 | ENST00000397514 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000429473 | ENST00000397515 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000429473 | ENST00000403747 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000429473 | ENST00000566587 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000429473 | ENST00000406620 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000429473 | ENST00000402301 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000430875 | ENST00000339021 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000430875 | ENST00000355803 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000430875 | ENST00000325437 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000430875 | ENST00000397514 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000430875 | ENST00000397515 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000430875 | ENST00000403747 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000430875 | ENST00000566587 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000430875 | ENST00000406620 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000430875 | ENST00000402301 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000428834 | ENST00000339021 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000428834 | ENST00000355803 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000428834 | ENST00000325437 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000428834 | ENST00000397514 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000428834 | ENST00000397515 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000428834 | ENST00000403747 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000428834 | ENST00000566587 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-3UTR | ENST00000428834 | ENST00000406620 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
| intron-intron | ENST00000428834 | ENST00000402301 | GNGT1 | chr7 | 93516673 | - | UBE2I | chr16 | 1375024 | + |
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FusionProtFeatures for GNGT1_UBE2I |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNGT1 | UBE2I |