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Fusion gene ID: 14934 |
FusionGeneSummary for GNB3_INTS9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNB3_INTS9 | Fusion gene ID: 14934 | Hgene | Tgene | Gene symbol | GNB3 | INTS9 | Gene ID | 2784 | 55756 |
| Gene name | G protein subunit beta 3 | integrator complex subunit 9 | |
| Synonyms | CSNB1H | CPSF2L|INT9|RC74 | |
| Cytomap | 12p13.31 | 8p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3G protein, beta-3 subunitGTP-binding regulatory protein beta-3 chainguanine nucleotide binding protein (G protein), beta polypeptide 3guanine nucleotide-binding protein G(I)/G(S)/G(T) bet | integrator complex subunit 9protein related to CPSF subunits of 74 kDa | |
| Modification date | 20180522 | 20180520 | |
| UniProtAcc | P16520 | Q9NV88 | |
| Ensembl transtripts involved in fusion gene | ENST00000229264, ENST00000435982, | ENST00000521022, ENST00000416984, ENST00000521777, ENST00000397363, ENST00000521070, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 4=100 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GNB3 [Title/Abstract] AND INTS9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | INTS9 | GO:0016180 | snRNA processing | 16239144 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM665849 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000229264 | ENST00000521022 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| 3UTR-intron | ENST00000229264 | ENST00000416984 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| 3UTR-intron | ENST00000229264 | ENST00000521777 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| 3UTR-intron | ENST00000229264 | ENST00000397363 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| 3UTR-intron | ENST00000229264 | ENST00000521070 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| intron-intron | ENST00000435982 | ENST00000521022 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| intron-intron | ENST00000435982 | ENST00000416984 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| intron-intron | ENST00000435982 | ENST00000521777 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| intron-intron | ENST00000435982 | ENST00000397363 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
| intron-intron | ENST00000435982 | ENST00000521070 | GNB3 | chr12 | 6956490 | - | INTS9 | chr8 | 28654528 | - |
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FusionProtFeatures for GNB3_INTS9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNB3 | INTS9 |