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Fusion gene ID: 14811 |
FusionGeneSummary for GMPR2_STOML2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GMPR2_STOML2 | Fusion gene ID: 14811 | Hgene | Tgene | Gene symbol | GMPR2 | STOML2 | Gene ID | 51292 | 30968 |
| Gene name | guanosine monophosphate reductase 2 | stomatin like 2 | |
| Synonyms | GMPR 2 | HSPC108|SLP-2 | |
| Cytomap | 14q12 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GMP reductase 2guanosine 5'-monophosphate oxidoreductase 2guanosine monophosphate reductase isolog | stomatin-like protein 2, mitochondrialEPB72-like 2EPB72-like protein 2paraprotein target 7paratarg-7stomatin (EPB72)-like 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9P2T1 | Q9UJZ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000355299, ENST00000559836, ENST00000559910, ENST00000399440, ENST00000420554, ENST00000348719, ENST00000557854, ENST00000559104, ENST00000456667, ENST00000560517, | ENST00000356493, ENST00000452248, ENST00000487490, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: GMPR2 [Title/Abstract] AND STOML2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GMPR2 | GO:0046037 | GMP metabolic process | 22037469 |
| Tgene | STOML2 | GO:0051259 | protein complex oligomerization | 17121834 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK075025 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000355299 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000355299 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000355299 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-3CDS | ENST00000559836 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000559836 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000559836 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-3CDS | ENST00000559910 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000559910 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000559910 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-3CDS | ENST00000399440 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000399440 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000399440 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-3CDS | ENST00000420554 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000420554 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000420554 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| Frame-shift | ENST00000348719 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| 5CDS-intron | ENST00000348719 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| 5CDS-intron | ENST00000348719 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| Frame-shift | ENST00000557854 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| 5CDS-intron | ENST00000557854 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| 5CDS-intron | ENST00000557854 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-3CDS | ENST00000559104 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000559104 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000559104 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-3CDS | ENST00000456667 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000456667 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000456667 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-3CDS | ENST00000560517 | ENST00000356493 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000560517 | ENST00000452248 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
| intron-intron | ENST00000560517 | ENST00000487490 | GMPR2 | chr14 | 24707667 | + | STOML2 | chr9 | 35101490 | - |
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FusionProtFeatures for GMPR2_STOML2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GMPR2 | STOML2 |