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Fusion gene ID: 14777

FusionGeneSummary for GLYCTK_PSG3

Fusion gene summary

Fusion gene information	Fusion gene name: GLYCTK_PSG3
	Fusion gene ID: 14777
		Hgene	Tgene
	Gene symbol	GLYCTK	PSG3
	Gene ID	132158	5671
	Gene name	glycerate kinase	pregnancy specific beta-1-glycoprotein 3
	Synonyms	HBEBP2\|HBEBP4\|HBeAgBP4A	-
	Cytomap	3p21.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	glycerate kinaseHBeAg binding protein 4HBeAg-binding protein 2	pregnancy-specific beta-1-glycoprotein 3PS-beta-G-3PSBG-3carcinoembryonic antigen SG5pregnancy-specific glycoprotein 3
	Modification date	20180523	20180519
	UniProtAcc	Q8IVS8	Q16557
	Ensembl transtripts involved in fusion gene	ENST00000461183, ENST00000305690, ENST00000473032, ENST00000354773, ENST00000471180, ENST00000436784, ENST00000477382,	ENST00000327495, ENST00000595140, ENST00000490592,
Fusion gene scores	* DoF score	2 X 2 X 2=8	7 X 8 X 1=56
	# samples	2	8
	** MAII score	log2(2/8*10)=1.32192809488736	log2(8/56*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GLYCTK [Title/Abstract] AND PSG3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GLYCTK	GO:0006468	protein phosphorylation	16753811

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BU752122	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000461183	ENST00000327495	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000461183	ENST00000595140	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000461183	ENST00000490592	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000305690	ENST00000327495	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000305690	ENST00000595140	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000305690	ENST00000490592	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000473032	ENST00000327495	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000473032	ENST00000595140	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000473032	ENST00000490592	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000354773	ENST00000327495	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000354773	ENST00000595140	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000354773	ENST00000490592	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000471180	ENST00000327495	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000471180	ENST00000595140	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000471180	ENST00000490592	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000436784	ENST00000327495	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000436784	ENST00000595140	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
3UTR-intron	ENST00000436784	ENST00000490592	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000477382	ENST00000327495	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000477382	ENST00000595140	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+
intron-intron	ENST00000477382	ENST00000490592	GLYCTK	chr3	52327412	-	PSG3	chr19	43262184	+

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FusionProtFeatures for GLYCTK_PSG3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GLYCTK Q8IVS8	PSG3 Q16557

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Fusion gene ID: 14777

FusionGeneSummary for GLYCTK_PSG3

FusionProtFeatures for GLYCTK_PSG3