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Fusion gene ID: 14766 |
FusionGeneSummary for GLUL_EIF2AK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLUL_EIF2AK2 | Fusion gene ID: 14766 | Hgene | Tgene | Gene symbol | GLUL | EIF2AK2 | Gene ID | 2752 | 5610 |
| Gene name | glutamate-ammonia ligase | eukaryotic translation initiation factor 2 alpha kinase 2 | |
| Synonyms | GLNS|GS|PIG43|PIG59 | EIF2AK1|PKR|PPP1R83|PRKR | |
| Cytomap | 1q25.3 | 2p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamine synthetasecell proliferation-inducing protein 59glutamate decarboxylaseglutamine synthaseproliferation-inducing protein 43 | interferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase, interferon-ind | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P15104 | P19525 | |
| Ensembl transtripts involved in fusion gene | ENST00000331872, ENST00000417584, ENST00000311223, ENST00000491322, ENST00000339526, | ENST00000233057, ENST00000395127, ENST00000405334, | |
| Fusion gene scores | * DoF score | 11 X 10 X 4=440 | 34 X 1 X 15=510 |
| # samples | 17 | 34 | |
| ** MAII score | log2(17/440*10)=-1.37196877738696 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(34/510*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GLUL [Title/Abstract] AND EIF2AK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GLUL | GO:0008283 | cell proliferation | 18662667 |
| Tgene | EIF2AK2 | GO:0006468 | protein phosphorylation | 19189853 |
| Tgene | EIF2AK2 | GO:0017148 | negative regulation of translation | 12882984 |
| Tgene | EIF2AK2 | GO:0035455 | response to interferon-alpha | 19840259 |
| Tgene | EIF2AK2 | GO:0046777 | protein autophosphorylation | 22801494 |
| Tgene | EIF2AK2 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15121867 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A0IM-01A | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000331872 | ENST00000233057 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000331872 | ENST00000395127 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000331872 | ENST00000405334 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000417584 | ENST00000233057 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000417584 | ENST00000395127 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000417584 | ENST00000405334 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000311223 | ENST00000233057 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000311223 | ENST00000395127 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| intron-intron | ENST00000311223 | ENST00000405334 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| 5CDS-intron | ENST00000491322 | ENST00000233057 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| 5CDS-intron | ENST00000491322 | ENST00000395127 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| 5CDS-intron | ENST00000491322 | ENST00000405334 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| 5CDS-intron | ENST00000339526 | ENST00000233057 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| 5CDS-intron | ENST00000339526 | ENST00000395127 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
| 5CDS-intron | ENST00000339526 | ENST00000405334 | GLUL | chr1 | 182352029 | - | EIF2AK2 | chr2 | 37342384 | - |
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FusionProtFeatures for GLUL_EIF2AK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLUL | EIF2AK2 |