|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 14741 |
FusionGeneSummary for GLOD4_NPLOC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLOD4_NPLOC4 | Fusion gene ID: 14741 | Hgene | Tgene | Gene symbol | GLOD4 | NPLOC4 | Gene ID | 51031 | 55666 |
| Gene name | glyoxalase domain containing 4 | NPL4 homolog, ubiquitin recognition factor | |
| Synonyms | C17orf25|CGI-150|HC71 | NPL4 | |
| Cytomap | 17p13.3 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glyoxalase domain-containing protein 4 | nuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homolog | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9HC38 | Q8TAT6 | |
| Ensembl transtripts involved in fusion gene | ENST00000575800, ENST00000301329, ENST00000301328, ENST00000536578, | ENST00000331134, ENST00000374747, ENST00000539314, ENST00000572760, ENST00000573876, ENST00000574344, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 9 X 7 X 8=504 |
| # samples | 3 | 11 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GLOD4 [Title/Abstract] AND NPLOC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-JV-A5VE-01A | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000575800 | ENST00000331134 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| intron-3CDS | ENST00000575800 | ENST00000374747 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| intron-5UTR | ENST00000575800 | ENST00000539314 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| intron-intron | ENST00000575800 | ENST00000572760 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| intron-intron | ENST00000575800 | ENST00000573876 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| intron-intron | ENST00000575800 | ENST00000574344 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| In-frame | ENST00000301329 | ENST00000331134 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| In-frame | ENST00000301329 | ENST00000374747 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-5UTR | ENST00000301329 | ENST00000539314 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000301329 | ENST00000572760 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000301329 | ENST00000573876 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000301329 | ENST00000574344 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| In-frame | ENST00000301328 | ENST00000331134 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| In-frame | ENST00000301328 | ENST00000374747 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-5UTR | ENST00000301328 | ENST00000539314 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000301328 | ENST00000572760 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000301328 | ENST00000573876 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000301328 | ENST00000574344 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| In-frame | ENST00000536578 | ENST00000331134 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| In-frame | ENST00000536578 | ENST00000374747 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-5UTR | ENST00000536578 | ENST00000539314 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000536578 | ENST00000572760 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000536578 | ENST00000573876 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
| 5CDS-intron | ENST00000536578 | ENST00000574344 | GLOD4 | chr17 | 673109 | - | NPLOC4 | chr17 | 79589304 | - |
Top |
FusionProtFeatures for GLOD4_NPLOC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLOD4 | NPLOC4 |