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Fusion gene ID: 14691 |
FusionGeneSummary for GLCE_NOX5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLCE_NOX5 | Fusion gene ID: 14691 | Hgene | Tgene | Gene symbol | GLCE | NOX5 | Gene ID | 26035 | 79400 |
| Gene name | glucuronic acid epimerase | NADPH oxidase 5 | |
| Synonyms | HSEPI | - | |
| Cytomap | 15q23 | 15q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-glucuronyl C5-epimeraseUDP-glucuronic acid epimeraseglucuronyl C5-epimeraseheparan sulfate C5-epimeraseheparan sulfate epimeraseheparin/heparan sulfate-glucuronic acid C5-epimeraseheparosan-N-sulfate-glucuronate 5-epimerase | NADPH oxidase 5NADPH oxidase, EF-hand calcium binding domain 5 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O94923 | Q96PH1 | |
| Ensembl transtripts involved in fusion gene | ENST00000261858, ENST00000559420, ENST00000559500, | ENST00000448182, ENST00000260364, ENST00000455873, ENST00000388866, ENST00000530406, ENST00000525163, | |
| Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/2*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: GLCE [Title/Abstract] AND NOX5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GLCE | GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 20118238 |
| Tgene | NOX5 | GO:0001935 | endothelial cell proliferation | 17275676 |
| Tgene | NOX5 | GO:0042554 | superoxide anion generation | 11483596 |
| Tgene | NOX5 | GO:0055114 | oxidation-reduction process | 11483596 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A09C-01A | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000261858 | ENST00000448182 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| 5UTR-5UTR | ENST00000261858 | ENST00000260364 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| 5UTR-intron | ENST00000261858 | ENST00000455873 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| 5UTR-intron | ENST00000261858 | ENST00000388866 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| 5UTR-intron | ENST00000261858 | ENST00000530406 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| 5UTR-intron | ENST00000261858 | ENST00000525163 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-5UTR | ENST00000559420 | ENST00000448182 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-5UTR | ENST00000559420 | ENST00000260364 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559420 | ENST00000455873 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559420 | ENST00000388866 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559420 | ENST00000530406 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559420 | ENST00000525163 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-5UTR | ENST00000559500 | ENST00000448182 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-5UTR | ENST00000559500 | ENST00000260364 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559500 | ENST00000455873 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559500 | ENST00000388866 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559500 | ENST00000530406 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
| intron-intron | ENST00000559500 | ENST00000525163 | GLCE | chr15 | 69453096 | + | NOX5 | chr15 | 69267068 | + |
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FusionProtFeatures for GLCE_NOX5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLCE | NOX5 |